AI Article Synopsis
- Many toxins pose serious threats to both humans and animals, but most lack specific antidotes.
- Recent advancements in CRISPR-Cas9 technology are helping to better understand how these toxins affect organisms at a genetic level.
- This review highlights the use of high-throughput CRISPR screens to analyze the interactions between toxins and their target tissues, along with important components and future research strategies in toxin studies.
Article Abstract
Many toxins are life-threatening to both animals and humans. However, specific antidotes are not available for most of those toxins. The molecular mechanisms underlying the toxicology of well-known toxins are not yet fully characterized. Recently, the advance in CRISPR-Cas9 technologies has greatly accelerated the process of revealing the toxic mechanisms of some common toxins on hosts from a genome-wide perspective. The high-throughput CRISPR screen has made it feasible to untangle complicated interactions between a particular toxin and its corresponding targeting tissue(s). In this review, we present an overview of recent advances in molecular dissection of toxins' cytotoxicity by using genome-wide CRISPR screens, summarize the components essential for toxin-specific CRISPR screens, and propose new strategies for future research.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489804 | PMC |
| http://dx.doi.org/10.1016/j.csbj.2022.09.012 | DOI Listing |
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