Osteosarcoma is one of the rarer malignancies that affects the facial skeletal structures. There are only a few retrospective studies discussing the management and outcomes of this malignancy due to the rarity of the disease. Unlike osteosarcoma of long bones, this malignancy has more incidence in patients in the older age group leading to difficulty in the management of this condition but with better outcomes due to the contrasting behavior of this malignancy. Osteosarcoma of the mandible has a longer median survival rate and lesser incidence of distant metastases. Osteosarcomas are more common in the appendicular skeleton, with the most prevalent sites being in the distal femur. Osteosarcoma of the mandible is a rare occurrence with management most commonly being a surgical intervention. Here, we present a 52-year-old female patient who was diagnosed to have osteosarcoma of the mandible treated with hemimandibulectomy and right sternocleidomastoid flap reconstruction with the final histopathology report as osteosarcoma-chondroblastic subtype.
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http://dx.doi.org/10.1007/s13193-022-01495-w | DOI Listing |
Cureus
November 2024
Histopathology, Jordanian Royal Medical Services, Amman, JOR.
Osteosarcoma (OS) is a rare form of malignant bone tumor affecting jaws. The diagnosis of jaws osteosarcoma (JO) presents a unique challenge due to its rarity and the diversity of histological presentations it can exhibit. Fibroblastic osteosarcoma (FO), a subtype of OS, is characterized by the presence of fibroblastic cells and osteoid-producing cells within the tumor matrix.
View Article and Find Full Text PDFCureus
November 2024
Department of Pediatric Dentistry, Medical University "Prof. Dr. Paraskev Stoyanov", Varna, BGR.
Cementoblastoma is a benign odontogenic mesenchymal tumor characterized by cementum production. Cementoblastoma is considered a relatively rare neoplasm with a predilection to the posterior region of the mandible. The main clinical differential diagnoses include hypercementosis, cemento-osseous dysplasia, condensing osteitis, idiopathic osteosclerosis, osteoblastoma, odontoma, and osteosarcoma.
View Article and Find Full Text PDFJ Maxillofac Oral Surg
December 2024
Independent Author, Private Practice: Prof. Dr. Celal Candirli, Istanbul, Turkey.
Head Neck Pathol
November 2024
Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Jaw osteosarcoma (JOS) is a rare, distinct variant that differ from long bone osteosarcoma (LBOS) in several aspects. JOS typically appears about twenty years later than LBOS, displays a lower propensity for metastasis to other organs, and exhibits better survival rates. The dissimilarities in clinical and biological behavior between JOS and LBOS are likely due, at least in part, to variations in their respective microenvironments.
View Article and Find Full Text PDFIn Vivo
October 2024
Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Kunming Medical University, Kunming, P.R. China;
Background/aim: To investigate the feasibility of establishing a mandibular osteosarcoma model in Sprague-Dawley (SD) rats using tissue block transplantation, providing a foundational model for osteosarcoma research.
Materials And Methods: Fourteen male SD rats, 3 weeks old and SPF grade, were randomly divided into a control group (n=4) and a mandibular osteosarcoma group (n=10). Using tissue block transplantation, UMR106 cell-induced tumor tissues were transplanted subcutaneously into the left mandibular marrow cavity of the SD rats.
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