AI Article Synopsis
- A cone-beam computed tomography system is less effective at identifying soft tissue targets due to low imaging contrast, prompting the development of a mobile bioluminescence tomography (BLT) system for improved localization in small animal irradiation.
- The BLT combines a light propagation model with optimization to generate detailed images of internal bioluminescent sources, achieving target localization accuracy within 1 mm.
- This technology offers researchers a new approach for precise, biology-guided radiation treatment for cancerous tissues by selecting optimal threshold and margin settings for target volumes.
Article Abstract
Due to low imaging contrast, a widely-used cone-beam computed tomography-guided small animal irradiator is less adept at localizing soft tissue targets. Bioluminescence tomography (BLT), which combines a model of light propagation through tissue with an optimization algorithm, can recover a spatially resolved tomographic volume for an internal bioluminescent source. We built a novel mobile BLT system for a small animal irradiator to localize soft tissue targets for radiation guidance. In this study, we elaborate its configuration and features that are indispensable for accurate image guidance. Phantom and validations show the BLT system can localize targets with accuracy within 1 mm. With the optimal choice of threshold and margin for target volume, BLT can provide a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484421 | PMC |
| http://dx.doi.org/10.1364/BOE.460737 | DOI Listing |
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