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Protein shapeshifting in necroptotic cell death signaling.
Trends Biochem Sci
December 2024
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following its activation by the upstream receptor-interacting protein kinase-3 (RIPK3), subsequent to activation of death, Toll-like, and pathogen receptors. The pathway originates in innate immunity, although interest has surged in therapeutically targeting necroptosis owing to its dysregulation in inflammatory diseases. Here, we explore how protein conformation and higher order assembly of the pathway effectors - Z-DNA-binding protein-1 (ZBP1), RIPK1, RIPK3, and MLKL - can be modulated by post-translational modifications, such as phosphorylation, ubiquitylation, and lipidation, and intermolecular interactions to tune activities and modulate necroptotic signaling flux.
View Article and Find Full Text PDFPredictive biosignatures for hospitalization in patients with virologically confirmed COVID-19.
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Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Background: COVID-19, caused by the SARS-CoV-2 virus, presents with varying severity among individuals. Both viral and host factors can influence the severity of acute and chronic COVID-19, with chronic COVID-19 commonly referred to as long COVID. SARS-CoV-2 infection can be properly diagnosed by performing real-time reverse transcription PCR analysis of nasal swab samples.
View Article and Find Full Text PDFImpressions on European physiology education and research-A quick view from the Portuguese experience.
Physiol Rep
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Universidade Lusófona, Lisbon, Portugal.
The Bologna Process and the European Higher Education Area (EHEA) are celebrating 25 years of free mobility and career opportunities. Despite its progress, disparities exist in the effectiveness of this initiative across EHEA countries. Physiology is a mandatory component of health science curricula but lacks standardized educational benchmarks, leading to limited societal awareness and professional opportunities.
View Article and Find Full Text PDFSynergy and competition during the anaerobic degradation of N-acetylglucosamine in a methane-emitting, subarctic, pH-neutral fen.
Front Microbiol
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Institute of Microbiology, Leibniz University Hannover, Hannover, Germany.
Peatlands are invaluable but threatened ecosystems that store huge amounts of organic carbon globally and emit the greenhouse gasses carbon dioxide (CO) and methane (CH). Trophic interactions of microbial groups essential for methanogenesis are poorly understood in such systems, despite their importance. Thus, the present study aimed at unraveling trophic interactions between fermenters and methanogens in a nitrogen-limited, subarctic, pH-neutral fen.
View Article and Find Full Text PDFRole of diaphragmatic ultrasound in patients with acute exacerbation of chronic obstructive pulmonary disease.
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Department of Medicine and Pharmacology, Texas A and M University, College Station, TX 77843, United States.
Assessing diaphragm function status is vital for diagnosing and treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Diaphrag-matic ultrasound has become increasingly important due to its non-invasive nature, absence of radiation exposure, widespread availability, prompt results, high accuracy, and repeatability at the bedside. The diaphragm is a crucial respiratory muscle.
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