AI Article Synopsis
- Cancer-associated fibroblasts (CAFs) are diverse cell types within tumors that contribute to tumor growth, spread, and resistance to treatment.
- These cells can originate from various sources, including regular fibroblasts, stem cells, and fat cells, leading to their varied functions and characteristics.
- The review highlights the role of CAFs in altering the tumor environment, supporting blood vessel formation, and releasing signaling molecules, underlining their potential as targets for cancer therapy.
Article Abstract
As an abundant component of tumor microenvironment, cancer-associated fibroblasts (CAFs) are heterogeneous cell populations that play important roles in tumor development, progression and therapeutic resistance. Multiple sources of cells can be recruited and educated to become CAFs, such as fibroblasts, mesenchymal stem cells and adipocytes, which may explain the phenotypic and functional heterogeneity of CAFs. It is widely believed that CAFs regulate tumor progression by remodeling extracellular matrix, promoting angiogenesis, and releasing soluble cytokines, making them a promising cancer therapy target. In this review, we discussed about the origin, subpopulation, and functional heterogeneity of CAFs, with particular attention to recent research advances and clinical therapeutic potential of CAFs in cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516766 | PMC |
| http://dx.doi.org/10.3389/fonc.2022.1008843 | DOI Listing |
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