The aim of this investigation was to assess the effectiveness of a combined treatment with stabilized and nonstabilized HA soft tissue fillers in the correction of midfacial volume and improving skin condition in the treated area. A total of 10 Caucasian female patients participated in the study, with a mean age of 42.2 years. They received stabilized and nonstabilized HA soft tissue fillers in the midface. Nonstabilized HA soft tissue filler was placed unilaterally. Skin density and thickness were measured with an ultrasound device. Aesthetic improvement and patient satisfaction were also assessed 3 weeks posttreatment. Side treated with stabilized and nonstabilized HA showed 65.40% increase in skin density versus the baseline and 7.02% increase in skin thickness versus the baseline. Side treated with stabilized HA showed 26.55% increase in skin density versus the baseline and 4.83% increase in skin thickness versus the baseline. After 3 weeks 62.5% of the patients stated that they were satisfied with the treatment and 37.5% of the patients were very satisfied with the treatment. Skin density and thickness significantly increased in the treated regions. Combined therapies based on stabilized and nonstabilized HA soft tissue fillers appear to be an optimal solution for facial volume and skin quality enhancement and seem to be more effective than stabilized HA soft filler alone. The procedure is safe and satisfactory to the treated subjects.
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