The relationship between Triglyceride and glycose (TyG) index and the risk of gynaecologic and breast cancers.

Background And Purpose: The relationship between triglyceride glucose (TyG) index and gynaecologic and breast cancers is unclear. We hypothesized that an increase in the TyG index is associated with elevated risk of cancers of the uterine, cervix, ovary and breast.

Methods And Results: For this observational study, we collected data from the National Health and Nutrition Examination Survey (NHANSE, 1999-2018). A total of 11466 individuals were included, involving 586 (5.1%) individuals with a previous cancer diagnosis in female reproductive tissues (i.e., breast, ovarian, cervical or uterine). Logistic regression was performed to evaluate the association between TyG index and incidence of gynaecologic and breast cancers. We observed that higher TyG index is significantly linked to greater prevalence of gynaecologic and breast cancers in US adult population. After adjustment of multi-variates, participants with the highest quartile of TyG index had an OR = 1.516 (95% confidence interval (CI) 1.121, 2.050) (P < 0.05) versus the lowest. In addition, TyG index was associated with the risk of female cancers of the breast OR per one standard deviation increase 2.25,95% confidence interval:1.50 to 3.37], cervix (1.68,0.99 to 2.84), ovary (3.73,1.01 to 13.87), uterine (2.42,1.14 to 5.16). The optimal cut-off value for predicting gynaecologic and breast cancers is 8.70. Kaplan-Meier curves showed that individuals (TyG index≥8.70) had higher cancer mortality (P value < 0.05).

Conclusions: The Elevated TyG index increases the incidence of cancers in female reproductive tissues. In the future studies, more evidence may be warranted to assess the correlation between TyG index and incidence of gynaecologic and breast cancers.