Advances in chitosan-based wound dressings: Modifications, fabrications, applications and prospects.

Carbohydr Polym

Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, China.

Published: December 2022

In the field of medical research, the development of safe and effective wound dressings is a continuous goal. Chitosan (CS) is highly sought after because of its unique biocompatibility, biodegradability, antibacterial, and healing-promoting properties. The CS molecule has a significant number of active amino and hydroxyl groups; thus, making substitutions and creating derivatives with varied biochemical properties are relatively straightforward processes. This review addresses the range of functions performed by CS and its derivatives in wound care, such as haemostasis, antibacterial, antioxidant, and wound healing. Furthermore, it summarises the various types of CS-based dressings, their performance features and applications. Finally, the future directions of CS-based dressings are proposed.

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http://dx.doi.org/10.1016/j.carbpol.2022.120058DOI Listing

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