Neuroimaging studies have shown that brain activity is variable and changes according to stimuli and the environmental context, reflecting brain coding or information representations at different processing levels. However, little is known about activity organization that reflects coding strategies. Here, we explored and compared two different coding approaches, spatial via cross-correlation and intensity-based coding using mutual information. Using two fMRI datasets and different seeds, we searched for the spatial and intensity-based similarities with the seeds in brain activity. Our results showed that, apart from the seed regions, significant regions detected by intensity-based similarity analysis differ completely from those found using cross-correlation. These findings may indicate that information shared through spatial coding differs from that transmitted via non-spatial coding processes. Our results suggest that brain coding is organized in several different ways to optimize information processing.
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