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Predicting the tumor microenvironment composition and immunotherapy response in non-small cell lung cancer from digital histopathology images.
NPJ Precis Oncol
December 2024
Department of Pathology and Laboratory Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Immune checkpoint inhibitors (ICI) have become integral to treatment of non-small cell lung cancer (NSCLC). However, reliable biomarkers predictive of immunotherapy efficacy are limited. Here, we introduce HistoTME, a novel weakly supervised deep learning approach to infer the tumor microenvironment (TME) composition directly from histopathology images of NSCLC patients.
View Article and Find Full Text PDFProbiotics and Phytobiotics as Dietary and Water Supplements in Biofloc Aquaculture Systems.
Aquac Nutr
December 2024
Commonwealth Scientific and Industrial Research Organization (CSIRO), CSIRO Agriculture and Food, Livestock and Aquaculture Program, Aquaculture Systems Team, Bribie Island Research Centre, Woorim, Australia.
Biofloc technology (BFT) is a relatively new microbial-based cultivation system that can be adopted to accomplish more sustainable aquaculture and circularity goals. This review explores aspects of BFT integrating the utilization of probiotics and phytobiotics as dietary and water supplements. This scientific-based snapshot unpacks some physiological pathways and brings a literature review on how these supplements can boost water quality, as well as aquatic species' growth, health, and survival.
View Article and Find Full Text PDFAgriculture assisted by microbial genetic resources: Current and future scenarios.
Curr Res Microb Sci
January 2024
Escuela Nacional de Ciencias Biológicas-IPN, C.P., Ciudad de México 11340, Mexico.
Microbial genetic resources, as part of world's biodiversity, are the backbone of all ecosystems. Their application in agri-food and industrial production has proven to be vital for the advancement of humankind. Today, amidst challenges stemming from population growth, climate change, shrinking arable land and increasing pollution, high-impact research on microbial genetic resources with the potential to strengthen the resilience of world agricultural production and safeguard human food security have been developed.
View Article and Find Full Text PDFThe Monitoring Illicit Substance Use Consortium: A Study Protocol.
JAACAP Open
December 2024
Deakin University, Geelong, Australia.
Objective: The global impact of substance use, including cannabis, amphetamine, cocaine, ecstasy, hallucinogens, and opioids, is increasing, although the overall prevalence is low. Australia and New Zealand are among the few regions of the world in which use (typically illicit) of these classes of substances remains within the top 10 causes of disease burden. The period of adolescence and young adulthood, during which substance use behaviors accelerate in prevalence, is associated with a particular risk for harm.
View Article and Find Full Text PDFKnowledge, attitude, and practice of healthcare workers towards healthcare- associated infections in Jimma University Medical Center, southwestern Ethiopia: using structural equation model.
BMC Health Serv Res
December 2024
Department of Internal Medicine, Institute of Health, Jimma University, Jimma, Ethiopia.
Background: Healthcare-associated infections (HCAIs) are a common challenge faced in healthcare facilities, particularly in low- and middle-income countries (LMICs). Evaluating the level of knowledge, attitude, and practice (KAP) among healthcare personnel regarding HCAI prevention and identifying the relevant factors is important for handling and controlling these infections. Therefore, this study aimed to assess the direct and indirect effects of knowledge, attitude, and practices of healthcare workers (HCW) towards HCAIs prevention in Jimma University Medical Center (JUMC).
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