AI Article Synopsis
- * Researchers conducted a detailed analysis of tumor and normal kidney samples from patients, revealing a specific gene expression pattern in ccRCC that can indicate how aggressive the cancer is and how long patients might survive.
- * The study also identified important interactions between tumor cells and their surrounding environment, suggesting that targeting certain molecular pathways (like CXCL9/CXCL10-CXCR3 and CD70-CD27) could lead to new treatment strategies for advanced ccRCC.
Article Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults. When ccRCC is localized to the kidney, surgical resection or ablation of the tumor is often curative. However, in the metastatic setting, ccRCC remains a highly lethal disease. Here we use fresh patient samples that include treatment-naive primary tumor tissue, matched adjacent normal kidney tissue, as well as tumor samples collected from patients with bone metastases. Single-cell transcriptomic analysis of tumor cells from the primary tumors reveals a distinct transcriptional signature that is predictive of metastatic potential and patient survival. Analysis of supporting stromal cells within the tumor environment demonstrates vascular remodeling within the endothelial cells. An in silico cell-to-cell interaction analysis highlights the CXCL9/CXCL10-CXCR3 axis and the CD70-CD27 axis as potential therapeutic targets. Our findings provide biological insights into the interplay between tumor cells and the ccRCC microenvironment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9525645 | PMC |
| http://dx.doi.org/10.1038/s41467-022-33375-w | DOI Listing |
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