AI Article Synopsis
- Two new compounds, sagittacins F and G, were discovered from the plant Ligularia sagitta, along with a known isomer of sagittacin F.
- The structures of these compounds were identified using spectroscopic methods, and their configurations were confirmed through X-ray spectroscopy.
- Anti-inflammatory properties were tested, showing that compounds 2 and 3 could modestly inhibit nitric oxide production in cells, with specific concentrations needed to achieve this effect.
Article Abstract
Two new eremophilane-type sesquiterpenoids, sagittacins F and G (1 and 2), together with one known isomer of sagittacin F (3) were isolated from the leaves and stems of Ligularia sagitta. Their structures were elucidated by interpretation of spectroscopic data and the absolute configurations of 1 and 3 were determined by X-ray spectroscopy. Compound 1 belongs to a rare class of eremophilane-type sesquiterpenoid featuring an α-oriented hydroxy group at C-1. A nitric oxide (NO) production inhibitory assay was applied to evaluate their anti-inflammatory activities by using LPS-induced RAW 264.7 cells. Compounds 2 and 3 exhibited modest NO production inhibitions with IC values of 45.15±2.72 and 49.83±2.34 μM, respectively.
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| http://dx.doi.org/10.1002/cbdv.202200762 | DOI Listing |
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