Introduction: African Americans (AA)s have worse inflammation, worse sleep, and a greater incidence of Alzheimer's disease (AD) compared to whites; however, no studies have examined associations between biomarkers, sleep, and cognition, and differences by race.

Methods: Seventy-six cognitively normal, middle aged (45-65 years) adults with a parental history of AD were included in this study. Associations between biomarkers (tumor necrosis factor-α [TNF-α], interleukin-10 [IL-10], intercellular adhesion molecule-1 [ICAM-1],, and C-reactive protein [CRP]) and self-reported sleep or cognition measures, were assessed.

Results: Average sleep duration was significantly lower for AA versus whites (average[SD]) in hours: 6.02(1.18) versus 7.23(0.91), = .000004). We found a statistically significant association between plasma IL-10 and sleep duration (Spearman's ρ = 0.26, = .04) and CSF ICAM-1 and sleep quality (Spearman's ρ = 0.30, = .03).

Discussion: Longer sleep duration is positively associated with plasma IL-10 levels irrespective of race. Sleep quality was positively associated with CSF ICAM-1 only in African Americans.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473642PMC
http://dx.doi.org/10.1002/trc2.12332DOI Listing

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