Introduction: African Americans (AA)s have worse inflammation, worse sleep, and a greater incidence of Alzheimer's disease (AD) compared to whites; however, no studies have examined associations between biomarkers, sleep, and cognition, and differences by race.
Methods: Seventy-six cognitively normal, middle aged (45-65 years) adults with a parental history of AD were included in this study. Associations between biomarkers (tumor necrosis factor-α [TNF-α], interleukin-10 [IL-10], intercellular adhesion molecule-1 [ICAM-1],, and C-reactive protein [CRP]) and self-reported sleep or cognition measures, were assessed.
Results: Average sleep duration was significantly lower for AA versus whites (average[SD]) in hours: 6.02(1.18) versus 7.23(0.91), = .000004). We found a statistically significant association between plasma IL-10 and sleep duration (Spearman's ρ = 0.26, = .04) and CSF ICAM-1 and sleep quality (Spearman's ρ = 0.30, = .03).
Discussion: Longer sleep duration is positively associated with plasma IL-10 levels irrespective of race. Sleep quality was positively associated with CSF ICAM-1 only in African Americans.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473642 | PMC |
http://dx.doi.org/10.1002/trc2.12332 | DOI Listing |
Cancer Causes Control
December 2024
Department of Clinical Nutrition, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, Anhui, China.
Breast cancer is the leading cause of cancer-related death and the most common cancer among women worldwide. It is crucial to identify potentially modifiable risk factors to intervene and prevent breast cancer effectively. Sleep factors have emerged as a potentially novel risk factor for female breast cancer.
View Article and Find Full Text PDFCommun Biol
December 2024
Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Dexmedetomidine (DexM), a highly selective α-adrenoceptor agonist, significantly reduces postoperative adverse effects, including sleep and circadian rhythm disruptions. Vasoactive intestinal peptide neurons in the suprachiasmatic nucleus (SCN) regulate the synchronization of circadian rhythms with the external environment in mammals. We investigate the effects of DexM on sleep and circadian rhythms, as well as the underlying mechanisms.
View Article and Find Full Text PDFSci Rep
December 2024
Center for Experimental Economics for Education, Shaanxi Normal University, 620 West Chang'an Street, Chang'an District, Xi'an, Shaanxi Province, China.
Adolescents in affluent nations have experienced a decline in sleep duration, associated with adverse outcomes such as behavioral issues and health concerns. However, the connection between sleep and mental well-being during adolescence, particularly in developing regions like rural China, remains underexplored. A cross-sectional study of 18,516 adolescents in 124 junior high schools in Ningxia, China, utilized the strengths and difficulties questionnaire to assess mental health.
View Article and Find Full Text PDFSci Rep
December 2024
Henan Children's Hospital Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, Henan Province, China.
This study aimed to assess its relationship between physical activity with health-related indicators in older population of the China. Cross-sectional data of 1,327 individuals aged 60-79 years were analyzed. Based on the Fifth National Physical Fitness Monitoring Program, depressive symptom and loneliness were measured using the Patient Health Questionnaire-9 and Emotional versus Social Loneliness Scales, respectively.
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Hefei, China; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China; Key Laboratory of Oral Diseases Research of Anhui Province, Stomatologic Hospital & College, Anhui Medical University, Hefei, Anhui, China; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, China. Electronic address:
Background: Light at night (LAN) has become a global concern. However, little is known about the effects of bedroom LAN exposure on glucose metabolism markers. We aimed to explore the association between intensity and duration of bedroom LAN exposure with glucose metabolism markers, and the role of circadian-dependent meal timing in these associations.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!