Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510739 | PMC |
| http://dx.doi.org/10.14744/hf.2021.2021.0050 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-desmethyl naproxen metabolite but not the acyl glucuronide.
Allergy
January 2024
Molecular& Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Article Synopsis
- Some anti-inflammatory drugs, like ibuprofen and naproxen, can cause a liver problem known as drug-induced liver injury (DILI) in some people, but we don't fully understand why this happens.
- In this study, researchers looked at the immune response in patients with DILI from ibuprofen and naproxen, focusing on special cells called T-cells that help fight off threats in the body.
- They discovered that a specific form of naproxen (called DM-NAP) activated these T-cells, showing that the immune system plays a role in this liver injury, but they didn’t find evidence linking naproxen itself to the liver damage.
NSAID-associated drug-induced liver injury prior to and following liver transplantation.
Hepatol Forum
September 2022
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkiye.
Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells.
Int J Mol Sci
August 2022
Department of Pharmacy, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashiosaka 577-8502, Osaka, Japan.
Non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (DIC) frequently induce drug-induced liver injury (DILI). It is unclear whether macrophages such as M1 and M2 participate in NSAID-associated DILI; elucidating this relationship could lead to a better understanding of the detailed mechanism of DILI. We co-cultured human hepatoma HepG2 cells with M1 or M2 derived from human monocytic leukemia THP-1 cells to examine the roles of M1 and M2 in DIC-induced cytotoxicity.
View Article and Find Full Text PDFMucoprotective drugs can prevent and treat nonsteroidal anti-inflammatory drug-induced small bowel enteropathy: a systematic review and meta-analysis of randomized controlled trials.
Therap Adv Gastroenterol
September 2021
Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Szigeti Street 12, Pécs 7624, Hungary.
Background: Small bowel enteropathy (SBE) is a complication of nonsteroidal anti-inflammatory drug (NSAID) therapy occurring in 71% of NSAID users. We aimed to analyse the efficacy and safety of medications to prevent and treat NSAID-induced SBE in randomized controlled trials (RCTs).
Methods: This review was registered on PROSPERO (CRD42021223371).
Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics.
Postgrad Med
March 2018
b Division of Gastroenterology and Hepatology , University of Virginia Medical School, Charlottesville , VA , U.S.A .
Over-the-counter (OTC) analgesics are routinely used worldwide for self-management of various painful conditions. Despite this, there has been little in-depth review of the safety of non-aspirin analgesics at OTC doses. This paper reviews the available literature on the gastrointestinal (GI) and hepatic safety of non-aspirin OTC analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs; ibuprofen, ketoprofen, diclofenac, and naproxen) and acetaminophen; safety in overdose is also reviewed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!