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Distinct local and brain-wide networks are activated by optogenetic stimulation of neurons specific to each layer of motor cortex. | LitMetric

Distinct local and brain-wide networks are activated by optogenetic stimulation of neurons specific to each layer of motor cortex.

Neuroimage

Department of Neurology and Neurological Sciences, Stanford University, CA 94305, USA; Department of Bioengineering, Stanford University, CA 94305, USA; Department of Neurosurgery, Stanford University, CA 94305, USA; Department of Electrical Engineering, Stanford University, CA 94305, USA. Electronic address:

Published: November 2022

AI Article Synopsis

  • - The primary motor cortex (M1) has six distinct layers (L1-L6) that play roles in motor control, but their specific influences and interactions within the brain are not fully understood.
  • - Researchers used advanced techniques like Cre-driver mouse lines, optogenetics, fMRI, and electrophysiology to investigate the circuitry of these layers, discovering that different neuron types in each layer have unique influences on M1 and other motor-related brain regions.
  • - The study found that the fMRI responses from stimulating specific neurons were related to changes in local brain activity (LFPs and spikes), improving our understanding of the layered structure of M1 and its role in the broader motor control network.

Article Abstract

Primary motor cortex (M1) consists of a stack of interconnected but distinct layers (L1-L6) which affect motor control through large-scale networks. However, the brain-wide functional influence of each layer is poorly understood. We sought to expand our knowledge of these layers' circuitry by combining Cre-driver mouse lines, optogenetics, fMRI, and electrophysiology. Neuronal activities initiated in Drd3 neurons (within L2/3) were mainly confined within M1, while stimulation of Scnn1a, Rbp4, and Ntsr1 neurons (within L4, L5, and L6, respectively) evoked distinct responses in M1 and motor-related subcortical regions, including striatum and motor thalamus. We also found that fMRI responses from targeted stimulations correlated with both local field potentials (LFPs) and spike changes. This study represents a step forward in our understanding of how different layers of primary motor cortex are embedded in brain-wide circuitry.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025169PMC
http://dx.doi.org/10.1016/j.neuroimage.2022.119640DOI Listing

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