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Diabetic ketoacidosis treatment outcomes and its associated factors among adult patients with diabetes mellitus admitted to public hospitals in Nekemte Town, Ethiopia: a cross-sectional study.
Front Clin Diabetes Healthc
January 2025
Department of Clinical Pharmacy, School of Pharmacy, Institute of Health Sciences, Wallaga University, Nekemte, Ethiopia.
Background: Diabetic ketoacidosis (DKA) is a serious and acute complication of diabetes mellitus. In Ethiopia, the mortality associated with acute diabetes complications ranges from 9.8% to 12%.
View Article and Find Full Text PDFTowards contrast-agnostic soft segmentation of the spinal cord.
Med Image Anal
January 2025
NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, Québec, Canada; Mila - Québec Artificial Intelligence Institute, Montréal, Québec, Canada; Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, Québec, Canada; Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada. Electronic address:
Spinal cord segmentation is clinically relevant and is notably used to compute spinal cord cross-sectional area (CSA) for the diagnosis and monitoring of cord compression or neurodegenerative diseases such as multiple sclerosis. While several semi and automatic methods exist, one key limitation remains: the segmentation depends on the MRI contrast, resulting in different CSA across contrasts. This is partly due to the varying appearance of the boundary between the spinal cord and the cerebrospinal fluid that depends on the sequence and acquisition parameters.
View Article and Find Full Text PDFProximity-activated guide RNA of CRISPR-Cas12a for programmable diagnostic detection and gene regulation.
Nucleic Acids Res
January 2025
Beijing Key Laboratory for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing 100083, China.
The flexibility and programmability of CRISPR-Cas technology have made it one of the most popular tools for biomarker diagnostics and gene regulation. Especially, the CRISPR-Cas12 system has shown exceptional clinical diagnosis and gene editing capabilities. Here, we discovered that although the top loop of the 5' handle of guide RNA can undergo central splitting, deactivating CRISPR-Cas12a, the segments can dramatically restore CRISPR function through nucleic acid self-assembly or interactions with small molecules and aptamers.
View Article and Find Full Text PDFExploring Mosquito Excreta as an Alternative Sample Type for Improving Arbovirus Surveillance in Australia.
Pathogens
January 2025
Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Geelong, VIC 3220, Australia.
Current arbovirus surveillance strategies in Australia involve mosquito collection, species identification, and virus detection. These processes are labour-intensive, expensive, and time-consuming and can lead to delays in reporting. Mosquito excreta has been proposed as an alternative sample type to whole mosquito collection, with potential to streamline the virus surveillance pipeline.
View Article and Find Full Text PDFA randomized sequential cross-over trial evaluating five purportedly ICP-lowering drugs in idiopathic intracranial hypertension.
Headache
January 2025
Translational Brain Science, Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Objective: To gain initial insight into the efficacy to lower intracranial pressure (ICP), side effects, and effects on cognition of five drugs commonly used to treat idiopathic intracranial hypertension (IIH).
Background: Limited clinical data exist for the treatment for IIH. Impaired cognition is recognized in IIH and can be exacerbated by medications.
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