AI Article Synopsis
- - The study investigates the roles of two Acetyl-coenzyme A synthetase proteins (BbAcs1 and BbAcs2) in the entomopathogenic fungus Beauveria bassiana, focusing on their contribution to metabolism and physiology.
- - BbAcs1 is involved in vegetative growth when using fatty acids for energy, while BbAcs2 significantly impacts lipid metabolism, blastospore formation, and the fungus's ability to infect hosts.
- - Overall, BbAcs2 is found to be more important than BbAcs1 for the fungus's lifestyle, linking its metabolism with its pathogenic characteristics.
Article Abstract
Acetyl-coenzyme A (CoA) synthetase (Acs) links cellular metabolism and physiology by catalyzing acetate and CoA into acetyl-CoA. However, the biological roles of Acs are not well studied in entomopathogenic fungi. In this study, two Acs proteins (BbAcs1 and BbAcs2) was functionally characterized in the filamentous insect pathogenic fungus Beauveria bassiana. BbAcs1 and BbAcs2 localize in cytoplasm and peroxisome, respectively. BbAcs1 contributes to vegetative growth on fatty acids as carbon source, and BbAcs2 did not. Both genes did not contribute to fungal response to stresses. The BbAcs1 loss conferred a slight influence on conidiation, and did not result in the defects in blastospore formation. On the contrary, BbAcs2 significantly contributes to lipid metabolism in germlings, blastospore formation, and virulence. The results indicated that Acs2 played a more predominant role than Acs1 in B. bassiana, which links the acetyl-CoA metabolism with the lifestyle of entomopathogenic fungi.
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| http://dx.doi.org/10.1007/s00203-022-03269-y | DOI Listing |
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