AI Article Synopsis
- The study focuses on developing a new type of theranostic sonosensitizer that combines sonodynamic therapy (SDT) and near infrared (NIR) imaging for better cancer treatment.
- Researchers created NIR-emitting carbon dots with special properties that enhance SDT effectiveness under low-intensity ultrasound.
- The new sonosensitizers can target cancer cells precisely, leading to successful complete destruction of tumors with just one injection and one session of irradiation.
Article Abstract
Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots containing both p- and n-type surface functionalization regions that can drive spatial separation of e-h pairs and fast transfer to reaction sites. Importantly, the cancer-specific targeting and high-level intratumor enrichment of the theranostic CDs are achieved by cancer cell membrane encapsulation for precision SDT with complete eradication of solid tumors by single injection and single irradiation. These results will open up a promising approach to engineer phosphorescent materials with long-lived triplet excited states for sonodynamic precision tumor therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523047 | PMC |
| http://dx.doi.org/10.1038/s41467-022-33474-8 | DOI Listing |
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