A new method of the synthesis of nanofibrillar cellulose/polystyrene composite based on ultrasonic treatment of styrene emulsion in cellulose-water solution was elaborated. A new approach does not require additional heating and proposes a significantly faster synthesis (15 min, 45 °C) of the target composite compared to the methods described previously. A comprehensive analysis did not reveal any significant differences between mechanical, physical and biodegradable properties of the composite obtained by ultrasonic method and that one obtained by conventional thermal method, which requires much higher temperature (above 75 °C) and reaction duration (from 3 h).
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http://dx.doi.org/10.1016/j.ultsonch.2022.106180 | DOI Listing |
J Biomed Mater Res A
January 2025
Department of Chemical & Biomolecular Engineering, University of Notre Dame, Notre Dame, USA.
Precise blood glucose control continues to be a critical challenge in the treatment and management of type 1 diabetes in order to mitigate both acute and chronic complications. This study investigates the development of a supramolecular peptide amphiphile (PA) material functionalized with phenylboronic acid (PBA) for glucose-responsive glucagon delivery. The PA-PBA system self-assembles into nanofibrillar hydrogels in the presence of physiological glucose levels, resulting in stable hydrogels capable of releasing glucagon under hypoglycemic conditions.
View Article and Find Full Text PDFAAPS PharmSciTech
December 2024
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra, 400056, India.
This research aimed to develop a mupirocin-doped α-cellulose nanopaper (MDAC-NP) as a wound dressing to accelerate wound healing while limiting localized bacterial growth. The α-cellulose nanofibrils suspension was prepared by ultrasonication followed by microfluidization and subsequently doped with 0.05% w/v mupirocin to prepare nanopaper (MDAC-NP-A).
View Article and Find Full Text PDFSci Adv
August 2024
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China.
Biomater Sci
October 2024
Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Traumatic musculoskeletal injuries that lead to volumetric muscle loss (VML) are challenged by irreparable soft tissue damage, impaired regenerative ability, and reduced muscle function. Regenerative rehabilitation strategies involving the pairing of engineered therapeutics with exercise have guided considerable advances in the functional repair of skeletal muscle following VML. However, few studies evaluate the efficacy of regenerative rehabilitation across the lifespan.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
August 2024
Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, 7610001 Rehovot, Israel.
Mechanical energy, specifically in the form of ultrasound, can induce pressure variations and temperature fluctuations when applied to an aqueous media. These conditions can both positively and negatively affect protein complexes, consequently altering their stability, folding patterns, and self-assembling behavior. Despite much scientific progress, our current understanding of the effects of ultrasound on the self-assembly of amyloidogenic proteins remains limited.
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