AI Article Synopsis
- HIV-HCV co-infected patients, once considered difficult to treat, showed high success rates (98.4% SVR12) with direct-acting antivirals (DAAs) for HCV treatment.
- The study included 201 patients, mostly males with a median age of 54, and reported minimal side effects like pruritus, headache, and fatigue.
- Six months after DAA treatment, there was a notable increase in CD4+ and CD8+ cell counts, particularly in patients who started with low CD4+ levels.
Article Abstract
Background: HIV-HCV co-infected patients have long been considered difficult-to-treat. The introduction of direct-acting antivirals (DAAs) changed this paradigm.We evaluated the efficacy and safety of DAA-based regimens and the impact of DAAs-induced HCV clearance on the immunological status in HIV-HCV co-infected patients.
Research Design And Methods: HIV patients starting HCV treatment with DAAs were included. Sustained virological response at 12 weeks after DAAs treatment (SVR12) was assessed. CD4+ and CD8+ blood cell count and CD4+/CD8+ ratio were recorded at baseline and six months post DAA treatment. We enrolled 201 patients, 76.1% males, median age 54 years, the most common genotypes 3 (29.8%) and 1a (29.4%), 40.3% with cirrhosis, 32.3% with prior interferon-based treatment. All patients were on antiretroviral treatment, 24.4% on methadone maintenance therapy and 22.6% on psychotropic drugs.
Results: SVR12 was 98.4%, the most common side effects were pruritus (8.4%), headache (7.4%) and fatigue (5.9%). An increase in CD4+ and CD8+ cell count was observed six months after completion of DAAs treatment, in particular in patients with low CD4+ cell count at baseline.
Conclusions: DAAs treatment resulted in high SVR12 rates, was well tolerated and Increased CD4+ and CD8+, especially in patients with low CD4+ cell count at baseline.
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| http://dx.doi.org/10.1080/14787210.2022.2130893 | DOI Listing |
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