AI Article Synopsis
- A new method for a 1,2-aminooxygenation reaction of 1,3-dienes uses dual photoredox and copper catalysis, making the process more effective.* -
- The reaction employs -aminopyridinium salts as sources of N-centered radicals and nucleophilic alcohols for oxygen, yielding 1,2-aminoalkoxylation products efficiently.* -
- Initial studies indicate that the reaction works through radical intermediates, supporting the proposed mechanism of the reaction.*
Article Abstract
A three-component 1,2-aminooxygenation reaction of 1,3-dienes by dual photoredox and copper catalysis is described. This protocol uses -aminopyridinium salts as N-centered radical precursors and nucleophilic alcohols as oxygen sources, providing modular and practical access to 1,2-aminoalkoxylation products with good yields and regioselectivity. Preliminary mechanistic studies support the radical property of the reaction and the involvement of N-centered radical intermediates.
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| http://dx.doi.org/10.1021/acs.orglett.2c03124 | DOI Listing |
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