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Regulation of T-independent B-cell responses by microRNA-146a. | LitMetric

Regulation of T-independent B-cell responses by microRNA-146a.

Front Immunol

Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, CA, United States.

Published: September 2022

The microRNA, miR-146a, is a negative feedback regulator of the central immune transcription factor, nuclear factor kappa B (NFkB). MiR-146a plays important roles in the immune system, and miR-146a deficient mice show a complex phenotype with features of chronic inflammation and autoimmune disease. In this study, we examined the role of miR-146a in extrafollicular B-cell responses, finding that miR-146a suppresses cellular responses and . Gene expression profiling revealed that miR-146a-deficient B-cells showed upregulation of interferon pathway genes, including , a known miR-146a target. We next interrogated the role of TRAF6 in these B-cell responses, finding that TRAF6 is required for proliferation by genetic and pharmacologic inhibition. Together, our findings demonstrate a novel role for miR-146a and TRAF6 in the extrafollicular B-cell responses, which have recently been tied to autoimmune disease pathogenesis. Our work highlights the pathogenetic role of miR-146a and the potential of pharmacologic inhibition of TRAF6 in autoimmune diseases in which miR-146a is deregulated.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511149PMC
http://dx.doi.org/10.3389/fimmu.2022.984302DOI Listing

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