Chiral Luminescent Sensor Eu-BTB@d-Carnitine Applied in the Highly Effective Ratiometric Sensing of Curing Drugs and Biomarkers for Diabetes and Hypertension.

Chiral drugs are of great significance in drug development and life science because one pair of enantiomers has a different combination mode with target biological active sites, leading to a vast difference in physical activity. Metal-organic framework (MOF)-based chiral hybrid materials with specific chiral sites have excellent applications in the highly effective sensing of drug enantiomers. Sitagliptin and clonidine are effective curing drugs for controlling diabetes and hypertension, while insulin and norepinephrine are the biomarkers of these two diseases. Excessive use of sitagliptin and clonidine can cause side effects such as stomach pain, nausea, and headaches. Herein, through post-synthetic strategy, MOF-based chiral hybrid material (HBTB = 1,3,5-benzenetrisbenzoic acid) was synthesized. has dual emission peaks at 417 and 616 nm when excited at 330 nm. can be applied in luminescent recognition toward sitagliptin and clonidine with high sensitivity and low detection limit (for sitagliptin detection, is 7.43 × 10 [M]; for clonidine detection, is 9.09 × 10 [M]; limit of detection (LOD) for sitagliptin is 10.21 nM, and LOD of clonidine is 8.34 nM). In addition, can further realize highly sensitive detection of insulin in human fluids with a high (2.08 × 10 [M]) and a low LOD (15.48 nM). On the other hand, norepinephrine also can be successfully discriminated by the hybrid luminescent platform of and clonidine with a high value of 4.79 × 10 [M] and a low LOD of 8.37 nM. As a result, the chiral hybrid material can be successfully applied in the highly effective ratiometric sensing of curing drugs and biomarkers for diabetes and hypertension.