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Clarkson disease in critically and non-critically ill patients: insights from the Italian IRIS-CLS registry.
Intern Emerg Med
March 2025
Division of Internal Medicine, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, University of Milan, Via G.B. Grassi 74, 20157, Milan, Italy.
Idiopathic Systemic Capillary Leak Syndrome (ISCLS) is a poorly understood paroxysmal permeability disorder. This study aimed to characterize the clinical features and severity markers of ISCLS in critically and non-critically ill patients. We analyzed prospectively and retrospectively collected data on ISCLS cases from the Italian IRIS-CLS Registry (January 1995-December 2023).
View Article and Find Full Text PDFRadiological Identification and Review of Lumbosacral Paraspinal Muscle Pyomyositis and Abscesses in a Young Male With Streptococcus Bacteremia: A Case Report.
Cureus
February 2025
Department of Translational Medicine, Florida International University, Herbert Wertheim College of Medicine, Baptist Health South Florida, Miami, USA.
We present a case report of a 21-year-old male patient with lumbosacral pyomyositis and abscesses secondary to , along with a review of the literature. The patient was admitted with acute metabolic encephalopathy, rhabdomyolysis secondary to cannabinoid use, acute kidney injury, and right lower extremity weakness. T2-weighted magnetic resonance imaging (MRI) of the lumbar region demonstrated multiple ring-enhancing nodular lesions within the left multifidus muscles, left erector spinae muscle, and left quadratus lumborum muscle.
View Article and Find Full Text PDFLate-Onset Multiple Acyl-CoA Dehydrogenase Deficiency Presenting as Hyperammonemia and Encephalopathy: Case Series.
Neurohospitalist
March 2025
Medical Genetics and Metabolism, Massachusetts General Hospital, Boston, MA, USA.
Multiple acyl-CoA dehydrogenase deficiency (MADD) is an inherited metabolic disorder (IMD) that affects the electron transfer chain and fatty acid oxidation. The late-onset form of MADD has a heterogenous clinical presentation that typically results in episodic lethargy, hypoglycemia, acidosis, and rhabdomyolysis during metabolic decompensations. In this case report series we describe three cases of late-onset MADD presenting with hyperammonemia and encephalopathy, a less frequent but severe complication.
View Article and Find Full Text PDFAcute Poisoning Due to an Intentional Overdose of 2,4-Dichlorophenoxyacetic Acid.
Cureus
March 2025
Endocrinology, Diabetes and Metabolism, HealthPartners, Minneapolis, USA.
Ethyl ester, chemically known as 2,4-dichlorophenoxyacetic acid (2,4-D), is a widely-used herbicide. It is recognized by the World Health Organization (WHO) as a Class II moderately hazardous herbicide, and its accidental or intentional ingestion can lead to multiorgan dysfunction and death. Overlap in presenting symptoms to other chemical poisonings makes it crucial to have a high clinical suspicion for this poisoning diagnosis.
View Article and Find Full Text PDFMultidisciplinary Case Review Committee: Comprehensive Referral Source for Evaluation and Treatment of High-Risk Exertional Injuries Fostering Safe and Expeditious Return to Duty Decisions.
Mil Med
March 2025
Consortium for Health and Military Performance, Department of Military and Emergency Medicine, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD 20814, USA.
Introduction: Exertion-related injuries (ERIs) affect Service Members (SM) worldwide with a direct impact on force readiness. Recent evidence has identified that the diagnostic coding of heat-related clinical illnesses can be subjective and prone to errors. Furthermore, ERIs, often have complex presentations impacting multiple organ systems.
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