The article presents an innovative concept for aging prevention of older citizens based on using elements of the International Classification of Functioning, Disability and Health which taking into account the influence of aging processes on changes in health and social adaptation of older citizens. The functional features of the departmental systems of health care and social protection of the population operating in Russia that impede their integration within the framework of providing comprehensive medical and social assistance to citizens of older age groups are analyzed. The biopsychosocial model of functioning and disability has advantages in comparison to another models given possibility of developing a social adaptation and implementation of an integrated systematic approach to the prevention of aging. A set of measures is proposed and justified to improve the efficiency, quality and accessibility of services health care for elderly by restructuring the functional interaction of departmental structures, attraction of resources and potential of non-governmental, public organizations, scientific and educational centers, professional communities and volunteers.
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Geroscience
January 2025
Department of Surgery, Immanuel Clinic Rüdersdorf, University Clinic of Brandenburg Medical School, Berlin, Germany.
Aging is a multi-organ disease, yet the traditional approach has been to study each organ in isolation. Such organ-specific studies have provided invaluable information regarding its pathomechanisms. However, an overall picture of the whole-body network (WBN) during aging is still incomplete.
View Article and Find Full Text PDFAgeing Res Rev
January 2025
Department of Dynamic and Clinical Psychology and Health, University of Rome "Sapienza", 00185 Rome, Italy. Electronic address:
Mild behavioral impairment (MBI) represents a recently introduced diagnostic concept that focuses on behavioral and personality changes occurring in late life and associated with cognitive decline. Nevertheless, the relationship between these dimensions remains unclear. This systematic review and meta-analysis aim to analyze the relationship between MBI and cognitive functioning.
View Article and Find Full Text PDFJ Women Aging
January 2025
Department of Sociology, European University at St. Petersburg, St Petersburg, Russia.
Women's sexuality as a dimension of embodied identity is shaped and constrained by social norms of gender and age and negotiated by women in complex ways. Discourses of hegemonic bodily normativity ascribe a sexless subjectivity to Russian women in their post-reproductive years, contributing to their social exclusion. At the same time, in modern Russian society a neoliberal concept of "successful active aging" is gradually changing understandings of aging, making later-life sexuality more visible and legitimate.
View Article and Find Full Text PDFJ Ginseng Res
January 2025
College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
DNA damage is a driver of cancer formation, leading to the impairment of repair mechanisms in cancer cells and rendering them susceptible to DNA-damaging therapeutic approaches. The concept of "synthetic lethality" in cancer clinics has emerged, particularly with the use of PARP inhibitors and the identification of DNA damage response (DDR) mutation biomarkers, emphasizing the significance of targeting DDR in cancer therapy. Novel approaches aimed at genome maintenance machinery are under development to further enhance the efficacy of cancer treatments.
View Article and Find Full Text PDFHealth Serv Res
January 2025
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Objective: To assess the utility and challenges of using natural language processing (NLP) in electronic health records (EHRs) to ascertain health-related social needs (HRSNs) among older adults.
Study Setting And Design: We extracted HRSN information using the NLP system Clinical Text Analysis and Knowledge Extraction System (cTAKES), combined with Concept Unique Identifiers and Systematized Nomenclature for Medicine codes. We validated cTAKES performance, via manual chart review, on two HRSNs: food insecurity, which was included in the healthcare system's HRSN screening tool, and housing insecurity, which was not.
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