Broad-spectrum antibiotics with once-daily dosing are often chosen for outpatient parenteral antibiotic therapy (OPAT) due to convenience even when narrower-spectrum antibiotics are appropriate. At our institution, up to 50% of select broad-spectrum OPAT regimens had potential to be narrowed, highlighting the need to re-evaluate regimens for de-escalation prior to discharge.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495413PMC
http://dx.doi.org/10.1017/ash.2021.204DOI Listing

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