AI Article Synopsis
- - The study evaluated how tumor regression grade (TRG) and nodal status affect survival rates in patients with esophageal cancer who received neoadjuvant chemoradiotherapy (nCRT) before surgery.
- - Analysis of survival rates showed that nodal status significantly impacts overall and disease-free survival, while TRG did not provide meaningful predictive value.
- - The researchers developed a modified TRG system by combining TRG with nodal status, which helps to better stratify patient survival outcomes and could guide future treatment decisions.
Article Abstract
Background: This study aimed to assess the predictive value of tumor regression grade (TRG) and nodal status on survival in esophageal carcinoma with neoadjuvant chemoradiotherapy (nCRT).
Methods: Tumor pathologic regression and nodal status were assessed. Differences in survival stratified by TRG or nodal status were analyzed using the Kaplan-Meier method and log-rank test. The prognostic value of TRG and nodal status were analyzed using univariate and multivariate Cox proportional hazards methods.
Results: From July 2016 to June 2019, 253 patients with esophageal cancer underwent nCRT followed by surgery. Significant differences were presented in survival according to nodal status but not TRG. Multivariate analysis showed that nodal status and not TRG was the only independent predicter for overall survival (HR: 3.550, 95% CI: 2.264-5.566, < 0.001) and disease-free survival (HR: 2.801, 95% CI: 1.874-4.187, < 0.001). The modified TRG system combining tumor regression with nodal status stratified patients survival with good discrimination.
Conclusions: Lymph node status impacts more importantly than TRG on survival for patients with esophageal cancer undergoing nCRT plus esophagectomy. The modified TRG system may facilitate postoperative treatment decisions and survival surveillance.
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| http://dx.doi.org/10.1080/08941939.2022.2127036 | DOI Listing |
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