AI Article Synopsis
- Enzymatic and cellular signaling biosensors help understand complex biological systems, especially those involving G protein-coupled receptors (GPCRs), which are major drug targets.
- There are many types of biosensors for GPCRs, each with different uses and functionalities, enhancing our knowledge of these proteins.
- This summary focuses on transducer biosensors that assess receptor-coupling and selectivity, particularly those that measure how GPCRs associate and activate heterotrimeric signaling complexes.
Article Abstract
Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in the human body, are plentiful and vary in utility, form and function. Their applications have continually expanded our understanding of this important protein class. Here, we briefly summarize a subset of this field with accelerating importance: transducer biosensors measuring receptor-coupling and selectivity, with an emphasis on sensors measuring receptor association and activation of heterotrimeric signalling complexes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511148 | PMC |
| http://dx.doi.org/10.1111/bph.15962 | DOI Listing |
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