Meanwhile, more than 600 different pharmaceuticals have been detected in surface water, with diclofenac, ethinylestradiol and cotrimoxazole as the frequently dominating substances. The highest concentrations of parent compounds, metabolites and transformation products were measured particularly in urban wastewater discharges, in liquid manure from animal husbandries and aquaculture facilities; however, the levels of certain psychopharmaceuticals and estrogen effective substances in surface water have been associated with behavioral changes and reproduction toxicity in fish species. As a consequence, in the near future measures must be implemented that noticeably reduce the discharge of pharmaceuticals into the environment. With respect to drinking water, the currently detected concentrations of active agents have so far not been found to reach toxicologically relevant concentrations for human beings. In contrast, swimming and bathing in receiving waters can be critical.
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