Background: The foci of distant metastasis from extramammary Paget's disease (EMPD) are the lung, liver, truncal bones, vertebrae, and brain. However, skull metastases have not been reported.

Observations: The authors treated a patient with calvarial and skull base metastases from EMPD who had undergone wide local resection of EMPD 8 years before, and they report his clinical course.

Lessons: Because EMPD with distant metastasis is fatal, it should be recognized that EMPD can metastasize to the skull even when it seemed to be in remission for several years.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514261PMC
http://dx.doi.org/10.3171/CASE22280DOI Listing

Publication Analysis

Top Keywords

skull metastases
8
extramammary paget's
8
paget's disease
8
distant metastasis
8
empd
5
skull
4
metastases extramammary
4
disease emerging
4
emerging years
4
years initial
4

Similar Publications

A 48-year-old female presented to the ED with worsening headache and neck pain for the past week. Her medical history is significant for recurrent left-sided triple-negative breast cancer (TNBC) with metastasis to the chest wall, liver, and lungs, initially diagnosed two years ago. She underwent a left-sided mastectomy and received radiation therapy and chemotherapy.

View Article and Find Full Text PDF

Primary intracranial neuroendocrine tumor at the sphenoid ridge with metastasis to the spinal cord: A case report.

Medicine (Baltimore)

December 2024

Department of Neurosurgery, Xiamen Branch of West China Hospital, Sichuan University, Xiamen, P.R. China.

Rationale: Neuroendocrine tumors (NETs) originate from neuroendocrine cells and they are depicted with both nerve cells as well as hormone-producing cells. These tumors were initially discovered in extracranial locations and central nervous system involvement is often a result of metastasis. Herein, we present a very rare case of primary intracranial neuroendocrine tumor (PINET) that masqueraded as meningioma at the sphenoid ridge with metastasis to the spinal cord in a patient without a known history of extracranial NET at the time of diagnosis.

View Article and Find Full Text PDF

This study aimed to assess the diagnostic capability of quantitative parameters from whole-body bone single-photon emission computed tomography/computed tomography (SPECT/CT) in detecting bone metastases in prostate cancer patients; Methods: We retrospectively analyzed 82 prostate cancer patients who underwent staging bone scintigraphy with a full-ring 360° Cadmium-Zinc-Telluride (CZT) SPECT/CT system. From the SPECT/CT images, we measured the maximum (SUVmax) and mean (SUVmean) standardized uptake values at six normal bone sites (skull, humerus, thoracic spine, lumbar spine, iliac bone, and femur), and the SUVmax for both metastatic and benign bone lesions. Ratios of lesion SUVmax-to-maximum and mean uptake values at the skull, humerus, and femur were computed for each lesion; Results: SUVmax and SUVmean at the skull and femur exhibited significantly lower variance compared to those at the thoracic spine, lumbar spine, and iliac bone, and revealed no significant differences between patients with and without bone metastasis.

View Article and Find Full Text PDF

Background: Metastatic follicular thyroid carcinoma to the central nervous system (CNS), including the skull and dura, is exceedingly rare.

Observations: The authors present the case of a gigantic, intraosseous, dural-based follicular thyroid carcinoma, highlighting the operative strategy for this mass. They also provide a literature review of CNS metastases of differentiated thyroid carcinoma.

View Article and Find Full Text PDF

Olfactory neuroblastoma: literature review and presentation of two clinical cases with different tumour infiltrations and different approaches.

Neurocirugia (Astur : Engl Ed)

December 2024

Departamento de Neurocirugía, Fundación Oftalmológica de Santander - Clínica Ardila Lülle, Floridablanca, Colombia. Electronic address:

The olfactory neuroblastoma is a rare malignant neoplasm derived from the olfactory neuroepithelium. It can metastasize to cervical lymph node chains and distant organs through hematogenous or lymphatic routes. Two clinical cases are presented: the first, a 56-year-old man with no pathological history, exhibited symptoms evolving over 2 months, characterized by persistent rhinorrhea with frequent epistaxis, ipsilateral proptosis, left hemicranial pain, anosmia, and dysgeusia.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!