AI Article Synopsis
- This systematic review and meta-analysis investigated complications from lung biopsies in patients suffering from acute respiratory failure (ARF), including acute respiratory distress syndrome (ARDS).
- The analysis included 13 studies with 574 patients and focused on outcomes like biopsy-related deaths, respiratory and cardiac complications, and other significant issues.
- Findings indicated a high median hospital mortality of 53%, with low rates of specific complications, providing important insights for deciding when to perform lung biopsies in ARF patients.
Article Abstract
Background: This systematic review and meta-analysis aimed to evaluate the complications of lung biopsy in patients with acute respiratory failure (ARF), including acute respiratory distress syndrome (ARDS).
Methods: We searched the MEDLINE and Cochrane Central Register of Controlled Trials. The primary outcomes were biopsy-related death, respiratory failure, cardiac complications, bleeding, and other major complications. We used the McMaster Quality Assessment Scale of Harms (McHarm) to evaluate the risk of bias. A random-effects model was used to calculate the pooled frequencies.
Results: Thirteen studies (consisting of 574 patients) were included in the meta-analysis. Furthermore, most of the included studies had a high or unclear risk of bias in half of the items in McHarm. All included studies evaluated surgical lung biopsies. The median overall hospital mortality was 53% (range: 17%-90%). The pooled frequencies of biopsy-related death, respiratory failure, cardiac complication, bleeding, and other major complications were 0.00% (95% confidence interval [CI]: 0.00%-0.21%), 1.30% (95% CI: 0.00%-5.69%), 1.03% (95% CI: 0.00%-3.73%), 1.46% (95% CI: 0.16%-3.56%), and 4.26% (95% CI: 0.00%-13.0%), respectively.
Conclusions: The results of this study will be valuable information in considering the indications of lung biopsy in patients with ARF, including ARDS.
Trial Registration: The protocol was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN 000040650).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501621 | PMC |
| http://dx.doi.org/10.1016/j.resinv.2022.08.008 | DOI Listing |
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