AI Article Synopsis
- GSTA4 plays a key role in regulating how melanoma cells respond to IFNγ and their ability to spread (metastasize).
- The study reveals a new way that cancer cells can avoid detection and destruction by the immune system.
- This escape mechanism involves enhancing their resistance to oxidative stress by increasing levels of GSTA4.
Article Abstract
Considering the importance of GSTA4 in controlling IFNγ responsiveness and the metastatic potential of other melanoma cells, our results highlight a novel mechanism whereby cancer cells escape from host immunity and gain metastatic ability by acquiring resistance to oxidative stress responses through the upregulation of GSTA4.
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| http://dx.doi.org/10.1158/1541-7786.MCR-22-0369 | DOI Listing |
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