Bleeding, Hemorrhagic Shock, and the Global Blood Supply.

Crit Care Clin

Program in Global Surgery and Social Change, Harvard Medical School, 641 Hungtington Avenue, Boston, MA 02115, USA; Division of Trauma & Emergency Surgery, Center for Surgery and Public Health, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02215, USA. Electronic address:

Published: October 2022

Hemorrhage is responsible for at least 40% of deaths after trauma and 27% of maternal deaths worldwide. Patients with hemorrhagic shock require attentive critical care and transfusion of blood products. Access to a safe and affordable blood supply is critical to providing safe surgical care. Traumatic injury, obstetric hemorrhage, and upper gastrointestinal bleed are the main causes of severe bleeding requiring transfusion. This article discusses the presentation and management of these causes across the world and provides a brief overview of the current challenges in maintaining a global blood supply.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccc.2022.06.013DOI Listing

Publication Analysis

Top Keywords

blood supply
12
hemorrhagic shock
8
global blood
8
bleeding hemorrhagic
4
shock global
4
blood
4
supply hemorrhage
4
hemorrhage responsible
4
responsible 40%
4
40% deaths
4

Similar Publications

The incidence of type 2 diabetes has risen globally, in parallel with the obesity epidemic and environments promoting a sedentary lifestyle and low-quality diet. There has been scrutiny of ultra-processed foods (UPFs) as a driver of type 2 diabetes, underscored by their increasing availability and intake worldwide, across countries of all incomes. This narrative review addresses the accumulated evidence from investigations of the trends in UPF consumption and the relationship with type 2 diabetes incidence.

View Article and Find Full Text PDF

Measurement and Analysis of Optical Transmission Characteristics of the Human Skull.

J Biophotonics

January 2025

Department of Emergency, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

The brain, as a vital part of central nervous system, receives approximately 25% of body's blood supply, making accurate monitoring of cerebral blood flow essential. While fNIRS is widely used for measuring brain physiology, complex tissue structure affects light intensity, spot size, and detection accuracy. Many studies rely on simulations with limited experimental validation.

View Article and Find Full Text PDF

Background: This study evaluates retinal oxygen saturation and vessel density within the macula and correlates these measures in controls and subjects with type 2 diabetes (DM) with (DMR) and without (DMnR) retinopathy. Changes in retinal oxygen saturation have not been evaluated regionally in diabetic patients.

Methods: Data from seventy subjects (28 controls, 26 DMnR, and 16 DMR were analyzed.

View Article and Find Full Text PDF

Quantitative pre-clinical imaging of hypoxia and vascularity using MRI and PET.

Methods Cell Biol

January 2025

Translational Radiomics, Luxembourg Institute of Health, Luxembourg City, Luxembourg; In-Vivo Imaging Platform, Luxembourg Institute of Health, Luxembourg City, Luxembourg.

During hypoxia, tissues are subjected to an inadequate oxygen supply, disrupting the balance needed to maintain normal function. This deficiency can occur due to reduced oxygen delivery caused by impaired blood flow or a decline in the blood's ability to carry oxygen. In tumors, hypoxia and vascularization play crucial roles, shaping their microenvironments and influencing cancer progression, response to treatment and metastatic potential.

View Article and Find Full Text PDF

Background: This study aims to demonstrate the 3-dimensional pattern of the nutrient vessels of the triquetrum using micro-computed tomography and determine the safe region for screw applications to the bone.

Methods: Seven fresh frozen cadavers' ulnar and radial arteries were injected with Microfil MV-117. Triquetral bones were dissected and examined using micro-computed tomography.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!