Orphaned oil and gas wells are unplugged nonproducing wells with no solvent owner of record to plug and mitigate them, such that the responsibility often falls on government agencies and the general public. Unplugged wells pose risks to the environment, climate, and human health. To develop a national framework to quantify the environmental benefits of plugging and optimize mitigation, we analyze oil and gas well data from state agencies across the United States to estimate the number of documented orphaned wells over time and evaluate their attributes. We find at least 81,857 documented orphaned wells as of September 2021 and 123,318 as of April 2022, representing 2% and 3%, respectively, of all estimated abandoned wells in the United States. We identify at least 20,286 potentially documented orphaned wells as of September 2021 (0.5% of all estimated abandoned wells in the country), of which 8% became documented orphaned wells as of April 2022. We estimate annual methane emissions to average 0.016 ± 0.001 MMt of CH for the 123,318 documented orphaned wells as of April 2022, corresponding to 5-6% of the total methane emissions estimated by the U.S. EPA for all abandoned wells. Although well type (i.e., oil vs gas) is generally available (83% of the 81,857 documented orphaned wells as of September 2021), only 49% and 16% of the wells have information on depth and last production date, respectively. Overall, documented orphaned wells and their attributes, including location, well type, depth, and last production date, require additional characterization and studies to constrain the uncertainties. Nevertheless, our identification and analysis of documented orphaned wells represent the first steps toward characterizing the full set of wells eligible to be plugged and remediated with the federal funding available in the U.S. via the Infrastructure Investment and Jobs Act. Our results can also be useful for the management of the hundreds of thousands, potentially a million, undocumented orphaned wells likely to exist across the nation.
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http://dx.doi.org/10.1021/acs.est.2c03268 | DOI Listing |
Virus Evol
January 2025
Institute of Western Agriculture, Chinese Academy of Agricultural Sciences, Changji 831100, China.
Advancements in high-throughput sequencing and associated bioinformatics methods have significantly expanded the RNA virus repertoire, including novel viruses with highly divergent genomes encoding "orphan" proteins that apparently lack homologous sequences. This absence of homologs in routine sequence similarity search complicates their taxonomic classification and raises a fundamental question: Do these orphan viral genomes represent viruses? In 2022, an orphan viral genome encoding a large polyprotein was identified in alfalfa () and thrips (), and named Snake River alfalfa virus (SRAV). SRAV was initially proposed as an uncommon flavi-like virus identified in a plant host distantly related to family .
View Article and Find Full Text PDFBMC Health Serv Res
January 2025
College of Pharmacy, Gyeongsang National University, 501 Jinju-Daero, Jinju, 52828, Republic of Korea.
Background: Innovative health technologies have increasingly emerged as a promising solution for patients with untreatable or challenging conditions. However, these technologies often come with expensive costs and limited evidence at the time of launch. This study assessed how these high-priced drugs with limited evidence were appraised and introduced in South Korea, England, Australia, and Canada, where cost-effectiveness analysis (CEA) generally plays a central role in pricing and reimbursement decisions.
View Article and Find Full Text PDFBMJ Open
December 2024
European Medicines Agency, Amsterdam, The Netherlands
Objectives: In the European Union, a new orphan medicinal product must demonstrate 'significant benefit' over approved medicinal products targeting the same indication. To demonstrate a significant benefit, comparisons between the new product and the already approved medicinal products-either directly by a head-to-head comparison within a clinical trial or indirectly as a cross-trial comparison-are necessary. In this study, we investigate the types of trial designs and statistical approaches used for demonstrating a significant benefit of a new orphan medicinal product against approved comparators used between 2012 and 2022.
View Article and Find Full Text PDFSci Rep
December 2024
Earth & Environmental Sciences Division, Los Alamos National Laboratory, Los Alamos, NM, 87544, USA.
To reduce environmental risks and impacts from orphaned wells (abandoned oil and gas wells), it is essential to first locate and then plug these wells. Manual reading and digitizing of information from historical documents is not feasible, given the large number of wells. Here, we propose a new computational approach for rapidly and cost-effectively characterizing these wells.
View Article and Find Full Text PDFSemergen
December 2024
Facultad de Medicina, Universidad de La Sabana, Chía, Colombia.
Introduction: Orphan diseases (OD) are rare but collectively common, presenting challenges such as late diagnoses, disease progression, and limited therapeutic options. Recently, artificial intelligence (AI) has gained interest in the research of these diseases.
Objective: To synthesize the available evidence on the use of AI in the comprehensive approach to orphan diseases.
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