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New Insights Into Hepatic Impairment (HI) Trials.
Clin Transl Sci
January 2025
Clinical Pharmacology, Translational Medicine and Clinical Pharmacology, Boehringer-Ingelheim Pharma, Ingelheim, Germany.
Hepatic impairment (HI) trials are traditionally part of the clinical pharmacology development to assess the need for dose adaptation in people with impaired metabolic capacity due to their diseased liver. This review aimed at looking into the data from dedicated HI studies, cluster these data into various categories and connect the effect by HI with reported pharmacokinetics (PK) properties in order to identify patterns that may allow waiver, extrapolations, or adapted HI study designs. Based on a ratio ≥ 2 or ≤ 0.
View Article and Find Full Text PDFA High-Throughput Screening Pipeline to Identify Methyltransferase and Exonuclease Inhibitors of SARS-CoV-2 NSP14.
Biochemistry
January 2025
National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
SARS-CoV-2 infections led to a worldwide pandemic in 2020. As of 2024, therapeutics against SARS-CoV-2 have continued to be desirable. NSP14 is a dual-function methyltransferase (MTase) and exonuclease (ExoN) with key roles in SARS-CoV-2 genome propagation and host immune system evasion.
View Article and Find Full Text PDFSpore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy.
Antioxidants (Basel)
December 2024
Horticulture College, Hunan Agricultural University, Changsha 410128, China.
Lipid accumulation and oxidative stress, which could be improved by autophagy, are the "hits" of metabolic-associated fatty liver disease (MAFLD). spore powder (GLSP) has the effect of improving liver function. However, there are few reports about its effects on and mechanisms impacting MAFLD alleviation.
View Article and Find Full Text PDFClick Ordering Lateralization Test: Applicability and feasibility of a new paradigm for assessing sound lateralization behavior.
Int J Pediatr Otorhinolaryngol
January 2025
Department of Physical Therapy, Speech-Language Pathology and Occupational Therapy, Medical School, University of São Paulo, São Paulo, 05360-160, Brazil.
Article Synopsis
- The study examined a new method for testing how well children can tell the direction of sounds.
- The Click Ordering Lateralization Test involved two tracks with 54 trials each, where kids identified the side they first heard noise bursts separated by different time intervals.
- Results showed that the method is reliable, with no significant differences between tracks, and it is suitable for assessing sound lateralization in children aged 8 to 14.
Dual Screen for Metal-Tolerant Metallophore Producers Evaluated with Soil from the Carpenter Snow Creek Site, a Heavy-Metal-Toxified Site in Montana.
ACS Omega
December 2024
Boudreau Lab, Department of Biomolecular Science, School of Pharmacy, University of Mississippi, Faser Hall University, University, Mississippi 38677-1848, United States.
Bacteria have evolved numerous mechanisms to resist metal toxicity, including small-molecule metal chelators (metallophores). This study presents a dual screening methodology to isolate metallophore-producing bacteria from the Carpenter Snow Creek Mining District for potential use in heavy-metal bioremediation. Soil samples were screened on metal-supplemented plates from which colonies were picked onto chrome azurol S (CAS)-dyed plates.
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