An increase in the number of reports of legionellosis in the European Union and the European Economic Area have been recorded in recent years. The increase in cases is significant: from 6947 reports in 2015 to 11,298 in 2019. This is alarming as genus Legionella, which comprises a large group of bacteria inhabiting various aquatic systems, poses a serious threat to human health and life, since more than 20 species can cause legionellosis, with L. pneumophila being responsible for the majority of cases. The ability to colonize diverse ecosystems makes the eradication of these microorganisms difficult. A detailed understanding of the Legionella habitat may be helpful in the effective control of this pathogen. This paper provides an overview of Legionella environments in Europe: natural (lakes, groundwater, rivers, compost, soil) and anthropogenic (fountains, air humidifiers, water supply systems), and the role of Legionella spp. in nosocomial infections, which are potentially fatal for children, the elderly and immunocompromised patients.
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http://dx.doi.org/10.1007/s11356-022-22950-9 | DOI Listing |
Antibiotics (Basel)
October 2024
UWA School of Agriculture and Environment, The University of Western Australia, Perth 6009, Australia.
mBio
November 2024
Department of Microbial Pathogenesis, Yale University, New Haven, Connecticut, USA.
Environ Microbiol
May 2024
Comparative Pathobiology Department, Purdue Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.
Free-living amoebae (FLA) serve as hosts for a variety of endosymbionts, which are microorganisms that reside and multiply within the FLA. Some of these endosymbionts pose a pathogenic threat to humans, animals, or both. The symbiotic relationship with FLA not only offers these microorganisms protection but also enhances their survival outside their hosts and assists in their dispersal across diverse habitats, thereby escalating disease transmission.
View Article and Find Full Text PDFBiofilm
June 2024
LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal.
There has been considerable discussion regarding the environmental life cycle of and its virulence potential in natural and man-made water systems. On the other hand, the bacterium's morphogenetic mechanisms within host cells (amoeba and macrophages) have been well documented and are linked to its ability to transition from a non-virulent, replicative state to an infectious, transmissive state. Although the morphogenetic mechanisms associated with the formation and detachment of the biofilm have also been described, the capacity of the bacteria to multiply extracellularly is not generally accepted.
View Article and Find Full Text PDFEur J Cell Biol
December 2023
Institut Pasteur, Université de Paris, Biologie des Bactéries Intracellulaires, 75724 Paris, France. Electronic address:
The study of virulence of Legionella pneumophila and its interactions with its hosts has been predominantly conducted in cellulo in the past decades. Although easy to implement and allowing the dissection of molecular pathways underlying host-pathogen interactions, these cellular models fail to provide conditions of the complex environments encountered by the bacteria during the infection of multicellular organisms. To improve our understanding of human infection, several animal models have been developed.
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