Unveiling the molecular features, relevant immune and clinical characteristics of in thyroid cancer.

The groundbreaking research work about has raised it as a potential promising target in cancer immunotherapy. Unfortunately, the role of in thyroid carcinoma (THCA) remains obscure. Public and home multi-omics data were collected to investigate the role of in THCA in our study. was upregulated in THCA tumor tissue compared to nontumor tissue in both mRNA and protein levels; gene set enrichment analysis (GSEA) results showed that high mRNA expression was positively correlated to many immune pathways. Results of the examination of immunological landscape characteristics displayed high mRNA expression that mainly positively correlated with a large number of cancer immunity immunomodulators and pathways. In addition, upregulation of was positively correlated with an enhanced immune score, stromal score, and estimate score. However, higher mRNA also met high immune exhausted status. The majority of CpG methylation sites negatively correlated with mRNA expression. Analysis of clinical characteristics supported increased expression that was positively correlated with more extrathyroid extension and lymph node metastasis. We observed different single nucleotide variant (SNV) and copy number variation (CNV) patterns in high and low mRNA expression subgroups; some vital DNA damage repair deficiency scores addressed a negative correlation with mRNA expression. We also found that some commonly used chemotherapy drugs might be suitable for different mRNA expression subgroups. This study highlighted the vital role of in THCA. Targeting may offer a potential novel therapeutic opportunity for THCA patients. However, the detailed exact cellular mechanisms of in THCA still needed to be elucidated by further studies.