Introduction: Oral anticancer therapy has the benefit of allowing cancer patients to carry out their treatment at home, without being inconvenienced or being at risk of nosocomial infection. However, non-adherence is a public health problem that contributes to the clinical decline of the patient and there are no studies submitted on the adherence of cancer patients to oral anti-anticancer agents in Santarém, PA.
Objective: In view of this, the general objective of this work was to evaluate this oral medication adherence.
Methods: The methodology consisted of a cross-sectional documentary study with a quantitative approach of patients seen at the pharmaceutical office. The Morisky-Green test was used to analyse the degree of adherence and descriptive and inferential statistics were used ( < 0.05).
Results: Patients' adherence to antitumour therapy was not 100%, the majority belonging to females; men were the most adherent, showing adverse reactions to anti-anticancer agents ( = 0.0096); comorbidity ( = 0.0202) negatively impacted adherence.
Conclusion: It is necessary to adopt new clinical procedures that can contribute to the management of these variables that prevent adherence, in order to improve the effectiveness of the treatment of these patients. There are circumstances that go beyond the aspects inherent to the patient, so it is also relevant to research the external factors that influence the individual's behaviour, such as the duration of therapy and the consequences of the treatment in the patient's routine.
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http://dx.doi.org/10.3332/ecancer.2022.1417 | DOI Listing |
Purpose: The Hematology Oncology Pharmacist Association Oral Chemotherapy Collaborative (HOPA OCC) developed practice-based tools to use in program development and improvement for the management of patients receiving oral anticancer agents (OAAs).
Methods: These tools include a baseline OAA program assessment, clinical OAA adherence tool, and OAA dashboard. HOPA OCC distributed these tools to teams participating in the 6-month HOPA ASCO Quality Training Programs (QTPs).
Int J Biol Macromol
January 2025
Department of Respiration, Liaocheng People's Hospital, Liaocheng, Shandong, China. Electronic address:
Lipid nanoparticles are obtaining significant attention in cancer treatment because of their efficacy at delivering drugs and reducing side effects. These things are like a flexible platform for getting anticancer drugs to the tumor site, especially upon HA modification, a polymer that is known to target tumors overexpressing CD44. HA is promising in cancer therapy because it taregtes tumor cells by binding onto CD44 receptors, which are often upregulated in cancer cells.
View Article and Find Full Text PDFCancer Nurs
January 2025
Author Affiliations: The Nethersole School of Nursing, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong (Ms Chen and Drs Ng, Zhang, and Chan); and Nursing Department, People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, China (Ms Chen).
Background: Patients with gastrointestinal tract cancer reported suboptimal adherence to oral anticancer agents (OAAs), reducing their therapeutic benefit and increasing mortality risk. A scoping review can comprehensively map available evidence on adherence to OAAs and inform appropriate support to improve treatment outcomes.
Objective: The aim of this study was to comprehensively map studies on adherence to OAAs among adults with gastrointestinal tract cancer, including the adherence rate, nonadherence reasons, influential factors, management strategies, and theories that guide these studies.
Minerva Dent Oral Sci
January 2025
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
Background: Boswellic acid (BA) is a bioactive compound derived from Boswellia trees. This study aims to investigate the anti-cancer properties of BA against KB oral squamous cancer cells and elucidate the underlying mechanisms.
Methods: Escalating doses of BA were administered to KB cells, and various analyses were conducted using bioinformatic tools such as GEO, GEO2R, and STITCH database.
Mol Biol Rep
January 2025
Laboratory of Biochemistry and Toxicology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Background: Lately, significant attention has been drawn towards the potential efficacy of cholera toxin (CT)-an exotoxin produced by the small intestine pathogenic bacterium Vibrio cholera-in modulating cancer-promoting events. In a recent study, we demonstrated that early-life oral administration of non-pathogenic doses of CT in mice suppressed chemically-induced carcinogenesis in tissues distantly located from the gut. In the mammary gland, CT pretreatment was shown to reduce tumor multiplicity, increase apoptosis and alter the expression of several cancer-related molecules.
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