Background: Malignant tumors of the appendix are extremely rare, constituting about 1% of all gastrointestinal tumors. Generally, pathology identifies these tumors during or after appendectomy because they are difficult to detect at the preoperative stage. This case report aims to introduce the definitive diagnosis and treatment of mucinous adenocarcinoma of the appendix.
Case Summary: A 49-year-old female patient came to our hospital with right lower abdominal pain, nausea, and vomiting for three days. There was no change in the menstrual cycle. Gynecological ultrasound showed a cystic, solid mass in the right adnexa. Abdominal enhanced computed tomography showed a thick appendix. Cancer was found on exploration of the appendix during gynecological surgery. The right colon was removed. After surgery, the patient received chemotherapy and is recovering well.
Conclusion: Appendiceal carcinoma is frequently found during or after surgery, and both preoperative examination and early evaluation of clinical manifestations are extremely important.
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http://dx.doi.org/10.12998/wjcc.v10.i22.8040 | DOI Listing |
Medicine (Baltimore)
December 2024
Department of General Surgery, Nujiang Prefecture People's Hospital, Nujiang, Yunnan, China.
Rationale: Low-grade appendiceal mucinous neoplasm (LAMN) is a clinically rare tumor that predominantly occurs in females and presents with nonspecific symptoms, often resulting in misdiagnosis. While postoperative pathology remains the gold standard for diagnosis, accurate preoperative identification through various diagnostic methods is essential for effective treatment planning. To raise awareness of this condition, we present a case of a middle-aged male diagnosed with LAMN.
View Article and Find Full Text PDFJ Transl Med
November 2024
Department of Myxoma, Aerospace Center Hospital, Beijing, 100049, China.
Background: Pseudomyxoma peritonei (PMP) is a rare malignant peritoneal tumor that readily recurs and metastasizes. Studies have shown that cancer stem cells (CSCs) play an important role in tumor recurrence, metastasis, and prognosis.
Objective: In this study, our aim was to isolate CSCs from various tissues of PMP patients and compare their proliferation, migration, and anti-inflammatory abilities.
Eur J Surg Oncol
January 2025
Department of General Surgery, Huzhou Central Hospital (The Affiliated Central Hospital of Huzhou University, The Fifth School of Clinical Medicine, Zhejiang Chinese Medical University, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine), Huzhou, 313000, China. Electronic address:
Background: the surgical treatment and prognostic characteristics of mixed adenoneuroendocrine carcinomas (MANEC) of the appendix are not yet available. In this study, we sought to figure out the choice of surgical approach (right hemicolectomy versus appendectomy), and explore the effect of chemotherapy on appendiceal MANEC.
Methods: patients with appendiceal MANEC from the Surveillance, Epidemiology, and End Results database (2000-2020) were stratified by gender, race, age group, tumor grade, and TNM stage.
Ann Surg Oncol
January 2025
Department of Surgery, Division of Surgical Oncology, Roger Williams Medical Center, Providence, RI, USA.
Background: Despite studies demonstrating that patients with peritoneal metastases from low-grade appendiceal adenocarcinoma (AA) do not respond well to systemic chemotherapy (SC), patients frequently undergo combination of SC with cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) regardless of grade.
Methods: A nationwide retrospective analysis using the National Cancer Database evaluated patients with AA with peritoneal metastasis from 2016 to 2021. Cox proportional hazards model was used to evaluate the impact of SC in addition to CRS/HIPEC on overall survival (OS) stratified by tumor grade.
Int J Surg Case Rep
December 2024
Department of Surgery, Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia.
Introduction: Collision tumors of the appendix are rare tumors consisting of two distinct pathologies arising from different cell lines simultaneously. The most common type is the coexistence of a neuroendocrine tumor (NET) with a low-grade appendiceal mucinous neoplasm (LAMN). We report a unique case of appendiceal collision tumor with synchronous cecal intra-mucosal carcinoma and pulmonary sarcoidosis.
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