AI Article Synopsis
- The 9p21 locus is a key area identified in genome-wide studies, linked to various diseases and cancers due to its genes for p16, p15, and p14 proteins.
- These proteins are vital for regulating the cell cycle and are associated with processes like aging and cellular regeneration.
- The review discusses how these genes are regulated and suggests potential strategies for targeting this locus in relation to diseases and aging.
Article Abstract
9p21 locus is one of the most reproducible regions in genome-wide association studies (GWAS). The region harbors genes that code for p16, p15, and p14 proteins, and it also harbors a long gene desert adjacent to these genes. The polymorphisms that are associated with several diseases and cancers are present in these genes and the gene desert region. These proteins are critical cell cycle regulators whose transcriptional dysregulation is strongly linked with cellular regeneration, stemness, aging, and cancers. Given the importance of this locus, intense scientific efforts on understanding the regulation of these genes via promoter-driven mechanisms and recently, via the distal regulatory mechanism have provided major insights. In this review, we describe these mechanisms and propose the ways by which this locus can be targeted in pathologies and aging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500187 | PMC |
| http://dx.doi.org/10.3389/fcell.2022.948351 | DOI Listing |
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