AI Article Synopsis
- - Mastocytosis is a rare disease with diverse characteristics that affect how it's treated and how well patients respond, generally categorized into cutaneous and systemic forms.
- - Diagnosing systemic mastocytosis (SM) is challenging and requires multiple specialists to assess clinical, biological, histological, and molecular information.
- - Gastrointestinal (GI) symptoms are prevalent in 14%-85% of patients with SM, affecting their quality of life significantly, and the review covers aspects like clinical presentations and treatment options for these GI issues.
Article Abstract
Mastocytosis is a rare and heterogeneous disease characterized by various clinical and biological features that affect different prognoses and treatments. The disease is usually divided into 2 principal categories: cutaneous and systemic disease (SM). Clinical features can be related to mast cell (MC) mediator release or pathological MC infiltration. SM is a disease often hard to identify, and the diagnosis is based on clinical, biological, histological, and molecular criteria with different specialists involved in the patient's clinical work-up. Among all manifestations of the disease, gastrointestinal (GI) symptoms are common, being present in 14%-85% of patients, and can significantly impair the quality of life. Here we review the data regarding GI involvement in SM, in terms of clinical presentations, histological and endoscopic features, the pathogenesis of GI symptoms, and their treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367223 | PMC |
| http://dx.doi.org/10.3748/wjg.v28.i29.3767 | DOI Listing |
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