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Diagnostic performance of C-TIRADS in malignancy risk stratification of thyroid nodules: A systematic review and meta-analysis. | LitMetric

AI Article Synopsis

  • C-TIRADS (Chinese thyroid imaging reports and data systems) is a new method for assessing the risk of malignancy in thyroid nodules, helping to guide fine needle aspiration (FNA) procedures.
  • A review of 16 studies involving over 11,000 thyroid nodules showed that C-TIRADS 4B had the best performance in diagnosing malignancies compared to other categories (4A and 4C).
  • C-TIRADS demonstrated strong diagnostic metrics, with a sensitivity of 94% and a specificity of 70%, indicating its effectiveness in identifying cancerous nodules.

Article Abstract

Background: Chinese thyroid imaging reports and data systems (C-TIRADS) is a novel malignancy risk stratification used for thyroid nodule diagnosis and guiding thyroid fine needle aspiration (FNA). In this review, we aim to assess the performance of C-TIRADS in malignancy risk stratification of thyroid nodules.

Methods: PubMed, Medline, Web of Science, Embase, CNKI, and Wanfang databases were searched until 1 April 2022. Original articles reporting data about C-TIRADS and setting FNA or histology as reference standards were included. C-TIRADS 4A, 4B, and 4C were set as thresholds, respectively, to obtain pooled sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), diagnostic odds ratio (DOR), and the area under the curve (AUC). Integrated nested Laplace approximation was used for Bayesian bivariate meta-analysis of diagnostic tests.

Results: Sixteen studies were included, evaluating 11,506 thyroid nodules. The rate of malignancy in each risk classification is comparable with that in C-TIRADS. C-TIRADS 4B appeared to have better diagnostic performance than C-TIRADS 4A and 4C. The pooled sensitivity, specificity, LR+, LR-, and DOR of C-TI-RADS 4B were 0.94 (95% CI: 0.89-0.97), 0.70 (95% CI: 0.60-0.79), 3.20 (95% CI: 2.28-4.39), 0.09 (95% CI: 0.05-0.15), and 33.71 (95% CI: 25.51-42.40), respectively. The area under the summary ROC curve was 0.94 (95% CI: 0.90-0.96).

Conclusion: C-TIRADS performed well in malignancy risk stratification of thyroid nodules. C-TIRADS 4B showed strong evidence of detecting malignancy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492922PMC
http://dx.doi.org/10.3389/fendo.2022.938961DOI Listing

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