AI Article Synopsis
- Cognitive impairment is a significant issue for patients with chronic kidney disease (CKD), affecting their overall well-being.
- Factors such as vascular damage, inflammation, and toxins from CKD contribute to brain damage, leading to cognitive decline.
- The review explores the causes, risk factors, and potential treatments for cognitive impairment in CKD, emphasizing the need for better understanding and innovative therapies.
Article Abstract
Background: Cognitive impairment, increasingly recognized as a major social burden, is commonly found in chronic kidney disease (CKD) patients.
Summary: Vascular damage, uremic toxicity, oxidative stress, and peripheral/central inflammation induced by CKD might be involved in brain lesions and ultimately result in cognitive decline. Uncovering the pathophysiology of CKD-associated cognitive impairment is important for early diagnosis and prevention, which undoubtedly prompts innovative pharmacological treatments.
Key Messages: Here, we sequentially review the current understanding and advances in the epidemiology, risk factors, and pathological mechanisms of cognitive impairment in CKD. Furthermore, we summarize the currently available therapeutic strategies for cognitive impairment in CKD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386403 | PMC |
| http://dx.doi.org/10.1159/000524475 | DOI Listing |
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