Background: Numerous challenges exist in determining surgical margin status. Communication between surgeons and pathologists is crucial for specimen orientation and accurate margin assessment.
Methods: A prospective study to determine feasibility of incorporating three-dimensional (3D) scanning into surgical pathology workflow was performed. A structured-light 3D scanner captured the photorealistic surface topography of fresh surgical specimens. Computer-aided design (CAD) software was used to document sites of margin sampling and sectioning. Surveys were distributed among faculty and staff stakeholders to assess feasibility.
Results: A series of 40 cases were 3D-scanned. Median image acquisition time was 8 min. The majority of respondents agreed that the experimental 3D system helped achieve clearer communication. 3D specimen maps assisted in the communication of a focally positive or close margin in 4 of 17 cases.
Conclusions: Routine 3D scanning and specimen mapping is feasible and represents an innovative approach to intraoperative and final pathology documentation, margin analysis, and surgeon-pathologist communication.
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http://dx.doi.org/10.1002/hed.27201 | DOI Listing |
Int J Implant Dent
December 2024
Department for Prosthetic Dentistry and Materials, University Medical Centre, Augustusplatz 2, 55131, Mainz, Germany.
Purpose: This study assesses the impact of Cold Atmospheric Pressure Plasma (CAP) pretreatment on the bond strength of two-piece hybrid ceramic abutment crowns in implant dentistry. The objective is to ascertain whether CAP can be employed as an alternative or complementary technique to conventional methods.
Methods: 80 titanium bases and 80 VITA ENAMIC polymer-infiltrated ceramic network (PICN) crowns were divided into 8 groups (n = 10) based on different surface pretreatments of the crowns before cementation: no treatment (A), hydrofluoric acid (HF) (B), HF and silane (C), silane (D), CAP (AP), HF and CAP (BP), HF, CAP, and silane (CP), and CAP and silane (DP).
Chem Biodivers
December 2024
Sao Paulo State University Julio de Mesquita Filho: Universidade Estadual Paulista Julio de Mesquita Filho, Biochemistry and Organic Chemistry, Professor Francisco Degni Avenue, 55, 14800-900, Araraquara, BRAZIL.
Dengue, a mosquito-borne disease transmitted by Aedes mosquitoes, is a significant global health concern. Despite extensive research, effective treatments remain limited. The indole nucleus, known for its diverse pharmacological properties, has emerged as a promising scaffold for anti-dengue drug discovery.
View Article and Find Full Text PDFChem Biodivers
December 2024
Daffodil International University, Pharmacy, Dhaka 1207, 1207, Dhaka, BANGLADESH.
The study investigates the inhibitory properties of Mangiferin and Friedelin against glucokinase, DPP-IV, α-amylase, and α-glucosidase using computational methods, in vitro enzyme assays, and in-depth ADMET analysis. The study utilized a computer-aided drug design approach to assess the potential therapeutic properties of Mangiferin and Friedelin as T2DM therapeutic agents. Molecular docking studies' outcomes encouraged the evaluation of both compounds in in vitro enzymatic assays.
View Article and Find Full Text PDFBiotechnol J
December 2024
Department of Biomedical Engineering, Tulane University, New Orleans, USA.
Microphysiological systems (MPS) containing perfusable vascular beds unlock the ability to model tissue-scale elements of vascular physiology and disease in vitro. Access to inexpensive stereolithography (SLA) 3D printers now enables benchtop fabrication of polydimethylsiloxane (PDMS) organ chips, eliminating the need for cleanroom access and microfabrication expertise, and can facilitate broader adoption of MPS approaches in preclinical research. Rapid prototyping of organ chip mold designs accelerates the processes of design, testing, and iteration, but geometric distortion and surface roughness of SLA resin prints can impede the development of standardizable manufacturing workflows.
View Article and Find Full Text PDFJ Esthet Restor Dent
December 2024
Department of Prosthodontics and Research Institute of Oral Science, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea.
Objectives: To evaluate the complementary mechanical properties of dental ceramics using edge chipping resistance (Rea) and flexural strength before and after thermomechanical aging.
Material And Methods: Computer-aided design and computer-aided manufacturing of ceramic materials, including zirconia (ZR), lithium disilicate (LS2), and resin nanoceramics (RNC), were evaluated. Specimens for flexural strength testing were fabricated with dimensions of 3 × 4 × 25 mm, with 30 specimens per group.
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