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Improving Participant Recruitment in Clinical Trials: Comparative Analysis of Innovative Digital Platforms.
J Med Internet Res
December 2024
Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Background: Pharmaceutical product development relies on thorough and costly clinical trials. Participant recruitment and monitoring can be challenging. The incorporation of cutting-edge technologies such as blockchain and artificial intelligence has revolutionized clinical research (particularly in the recruitment stage), enhanced secure data storage and analysis, and facilitated participant monitoring while protecting their personal information.
View Article and Find Full Text PDFAn updated review for clinical and radiological predictors of acute intraparenchymal hematoma progression in cerebral contusion.
Heliyon
November 2024
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Backgrounds: The rapid expansion of an intraparenchymal hematoma following cerebral contusion often results in high mortality rates and a poor prognosis. Effective tools are essential for predicting and monitoring the incidence of traumatic intraparenchymal hematoma (tICH) and identifying patients at high risk of tICH expansion. This enables timely surgical interventions and appropriate medical management.
View Article and Find Full Text PDFNatural course of the acute unruptured intracranial vertebral artery dissections which show pearl-and-string sign.
Neurochirurgie
November 2024
Department of Neurosurgery, Konkuk University School of Medicine, Seoul, South Korea. Electronic address:
Introduction: Ruptured vertebral artery dissections frequently exhibit pearl-and-string signs, a characteristic also observed in many unruptured dissections. This study examines the natural course of 50 unruptured acute vertebral artery dissections presenting with pearl-and-string signs and compares them to 10 ruptured dissections of the same morphological pattern.
Methods: We reviewed 633 radiology reports of head and neck imaging studies that included the keyword 'dissection'.
Diagnostic performance of intracystic carcinoembryonic antigen (CEA) versus glucose in differentiation of mucinous and non-mucinous pancreatic cysts.
Pathol Oncol Res
October 2024
Department of Surgery, Transplantation and Gastroenterology, Division of Interventional Gastroenterology, Semmelweis University, Budapest, Hungary.
Article Synopsis
- Pancreatic cysts vary in their risk of cancer, making it important to differentiate between mucinous and non-mucinous types, as mucinous cysts can become malignant.
- This study compares the effectiveness of measuring intracystic glucose and carcinoembryonic antigen (CEA) levels using endoscopic ultrasound for diagnosing these cysts, involving data from 91 patients who had fine-needle aspiration.
- Results showed that while intracystic glucose is highly sensitive (96.2%) for identifying mucinous cysts, its specificity (79.5%) is lower compared to CEA, which is very specific (100%) but less sensitive (69.2%).
A Novel Ultrasound Finding for the Diagnosis of Giant Cell Arteritis: Comparison With Temporal Artery Biopsy Findings.
J Clin Ultrasound
October 2024
Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Article Synopsis
- - The hypoechoic halo is a common ultrasound finding in giant cell arteritis (GCA), but it can sometimes be misinterpreted due to arteriosclerosis.
- - Researchers investigated the specific distribution of GCA lesions and introduced the "string of beads sign" to assess luminal irregularities in long-axis images.
- - The study found that combining the string of beads sign with the hypoechoic halo improved diagnostic accuracy for GCA, showing a C-statistic of 1.00 compared to 0.89 for the halo alone.
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