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| http://dx.doi.org/10.1186/s13578-022-00878-4 | DOI Listing |
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CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally.
Cell Syst
January 2025
Department of Biochemistry & BioFrontiers Institute, University of Colorado, Boulder, CO 80303, USA. Electronic address:
The mitogen-activated protein kinase (MAPK) pathway integrates growth factor signaling through extracellular signal-regulated kinase (ERK) to control cell proliferation. To study ERK dynamics, many researchers use an ERK activity kinase translocation reporter (KTR). Our study reveals that this ERK KTR also partially senses cyclin-dependent kinase 2 (CDK2) activity, making it appear as if ERK activity rises as cells progress through the cell cycle.
View Article and Find Full Text PDFScoping review of robotics technology in spinal surgery with highlights of the Annual Seattle Science Foundation Course.
Ann Transl Med
December 2024
Department of Neurosurgery, Providence Neuroscience Center Everett, Everett, WA, USA.
Background: Robotic assistance has become increasingly prevalent in spinal surgery in recent years, emerging as a tool to increase accuracy and precision and lower complication rates and radiation exposure. The 7 and 8 Annual Seattle Science Foundation (SSF) Robotics Courses showcased presentations and demonstrations from some of the field's most experiences leaders on latest topics in robotics and spinal surgery, including cutting-edge preoperative planning technologies, augmented reality (AR) in the operating room, cervical fusion with transpedicular screws, and neuro-oncologic management. We provide a scoping review of the use of robotics technology in spinal surgery featuring highlights from the 7 and 8 Annual SSF Robotics Courses.
View Article and Find Full Text PDFIntegrating epigenetic modification and stem cell therapy strategies: A novel approach for advancing Alzheimer's disease treatment - A literature review.
Narra J
December 2024
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Alzheimer's disease (AD) is the most frequent form of dementia and represents an increasing global burden, particularly in countries like Indonesia, where the population has begun to age significantly. Current medications, including cholinesterase inhibitors and NMDA receptor antagonists, have modest effects on clinical symptoms in the early to middle stages, but there is no curative treatment available so far despite progress. Activating or repressing epigenetic modifications, including DNA methylation, histone modification and microRNA regulation, appears to play an important role in AD development.
View Article and Find Full Text PDFThree-dimensional high-isotropic-resolution MR fingerprinting optimized for 0.55 T.
Magn Reson Med
January 2025
Department of Radiology, Stanford University, Stanford, California, USA.
Purpose: To provide a fast quantitative imaging approach for a 0.55T scanner, where signal-to-noise ratio is limited by the field strength and k-space sampling speed is limited by a lower specification gradient system.
Methods: We adapted the three-dimensional spiral projection imaging MR fingerprinting approach to 0.
We present a new, to the best of our knowledge, approach for self-heterodyne optical frequency comb (OFC) spectroscopy in which a single Mach-Zehnder modulator is utilized to generate both an optical frequency comb and a frequency-shifted local oscillator. This method allows for coherent, time-domain averaging to be performed without the need for feedback mechanisms or software corrections. As an initial demonstration, we have measured acetylene rovibrational transition frequencies with coherently averaged comb spectra.
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