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Acetyl-L-carnitine ameliorates atherosclerosis in LDLR mice by modulating cholesterol metabolism through SREBP2-dependent cholesterol biosynthesis.
Front Nutr
December 2024
Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing, China.
Background: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality globally. Hypercholesterolemia accelerates atherosclerotic development and is an independent modifiable risk factor for ASCVD. Reducing cholesterol levels is effective in preventing ASCVD.
View Article and Find Full Text PDFGut microbes with the genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition.
Gut Microbes
December 2025
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Gut microbial metabolism of L-carnitine, which leads to the production of detrimental trimethylamine N-oxide (TMAO), offers a plausible link between red meat consumption and cardiovascular risks. Several microbial genes, including , the operon, and the recently identified gene cluster, have been implicated in the conversion of dietary L-carnitine into TMA(O). However, the key microbial genes and associated gut microbes involved in this pathway have not been fully explored.
View Article and Find Full Text PDFEffects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs.
Front Med (Lausanne)
December 2024
Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran.
Background: Chronic kidney disease (CKD) affects 10% of the global population and leads to end-stage renal disease (ESRD). Hemodialysis is a common treatment for ESRD, but patients often have low carnitine levels, leading to dyslipidemia, a risk factor for cardiovascular disease and the leading cause of mortality. This study aimed to assess the effects of L-carnitine on lipid profiles in adult hemodialysis patients.
View Article and Find Full Text PDFMALDI-TOF Mass Spectrometry Reveals the Effect of Acetyl-L-Carnitine on the Lipid Profile of Buffalo Oocytes and Cumulus Cells During In Vitro Maturation.
Reprod Domest Anim
December 2024
College of Animal Science and Technology, Guangxi University, Nanning, China.
Lipids in cumulus-oocyte complexes are important actors in molecular signalling pathways and are influenced by maturation conditions. Acetyl-L-carnitine (ALC) is a carrier involved in fatty acid transport and is a promoter of β-oxidation. Although the embryonic development potential of oocytes can be improved when ALC is added to the maturation medium, the effects of ALC on the lipid content and composition of oocytes and cumulus cells remain unknown.
View Article and Find Full Text PDFCarnitine supplementation in progressive supranuclear palsy.
Nutr Clin Pract
December 2024
Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, Florida, USA.
Mitochondrial dysfunction has been implicated in the pathogenesis of several neurodegenerative disorders, including progressive supranuclear palsy (PSP). PSP is a Parkinsonian syndrome characterized by a rapidly progressive state that manifests itself as tremors, bradykinesia, and supranuclear gaze palsy. Carnitine plays an essential role in mitochondrial function by transporting fatty acids across the mitochondrial membrane to be used in energy production.
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