AI Article Synopsis
- A multidrug-resistant pathogen has become a global issue, particularly in healthcare settings, and whole genome sequencing (WGS) has revealed four major genetic clades.
- Recent findings confirm a potential fifth clade from Iran based on WGS data from four more isolates, showing minimal genetic variation among them (less than 100 SNPs).
- This fifth clade is significantly distinct from the other clades, with over 200,000 SNPs separating them, and two of the isolates demonstrate fluconazole resistance due to specific gene mutations.
Article Abstract
has emerged globally as a multidrug-resistant pathogen causing outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while earlier WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by providing WGS data of another four Iranian isolates. These clade V isolates differed less than 100 single-nucleotide polymorphisms (SNPs) between each other, while they were separated from the other clades by more than 200,000 SNPs. Two of these isolates were resistant to fluconazole and were found to harbour mutations in the and genes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586689 | PMC |
| http://dx.doi.org/10.1080/22221751.2022.2125349 | DOI Listing |
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