AI Article Synopsis
- Cell monolayers serve as a key model in understanding tissue biophysics, particularly in curved epithelial tissues' behavior.
- This research introduces a hydrodynamic theory for a specific type of gel on a curved surface, revealing that curvature significantly influences how these monolayers move compared to flat surfaces.
- Factors like surface curvature, friction, and active forces determine various flow patterns, affecting how motion transitions from smooth to abrupt.
Article Abstract
Cell monolayers are a central model system in the study of tissue biophysics. In vivo, epithelial tissues are curved on the scale of microns, and the curvature's role in the onset of spontaneous tissue flows is still not well understood. Here, we present a hydrodynamic theory for an apical-basal asymmetric active nematic gel on a curved strip. We show that surface curvature qualitatively changes monolayer motion compared with flat space: the resulting flows can be thresholdless, and the transition to motion may change from continuous to discontinuous. Surface curvature, friction, and active tractions are all shown to control the flow pattern selected, from simple shear to vortex chains.
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| http://dx.doi.org/10.1103/PhysRevLett.129.118001 | DOI Listing |
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