AI Article Synopsis
- The study evaluated how well the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and pulmonary comorbidity predict outcomes like non-relapse mortality (NRM) and overall survival (OS) in patients undergoing hematopoietic cell transplantation (HCT).
- In a review of 663 adult HCT recipients, patients were classified based on pulmonary comorbidity risk levels, and the predictive capability of this pulmonary comorbidity score (PCS) was compared to HCT-CI.
- Findings revealed that pulmonary comorbidity is a strong individual predictor of OS and NRM, outperforming HCT-CI in certain instances, particularly in groups undergoing myeloablative conditioning (MAC).
Article Abstract
Objectives: The purpose of the study was to assess the validity of the hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and of pulmonary comorbidity prior to HCT in terms of predicting non-relapse mortality (NRM) and overall survival (OS).
Methods: In this retrospective single-center study of 663 consecutive adult recipients of HCT, we stratified patients into groups by pulmonary comorbidity: low-risk, intermediate-risk, and high-risk. The predictive value of this pulmonary comorbidity score (PCS) was compared to HCT-CI.
Results: In univariate analysis, the HCT-CI and the PCS were associated with OS after transplantation when comparing patients in high-risk groups with patients in low-risk groups. Using the PCS, the hazard ratios (HRs) of the 2-year OS in the entire population and in the myeloablative conditioning (MAC) group were 1.98 (p < .001) and 3.27 (p < .001), respectively, whereas the HRs using the HCT-CI were 1.83 (p < .001) and 2.57 (p = .002). The 2-year NRM incidence in the three risk-groups in the entire population was significant using both indexes. In the MAC group, the 2-year NRM was significant using the PCS (p = .003), but not using the HCT-CI (p = .23).
Conclusions: Our study suggest that pulmonary function alone is a strong predictor of 2-year OS and NRM after HCT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092052 | PMC |
| http://dx.doi.org/10.1111/ejh.13869 | DOI Listing |
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